Intractable Epilepsies

  • Jean Régis
  • Fabrice Bartolomei
  • Patrick Chauvel


There are convincing arguments for investigating the potential role of radiosurgery in epilepsy surgery. We know that:
  • Radiosurgery (since its introduction in the 1950s) has been demonstrated to have advantages in terms of safety and efficacy, for the treatment of numerous small, deeply seated intracerebral lesions.

  • Radiosurgical treatment of small cortico-subcortical lesions associated with epilepsy has been demonstrated to lead to seizure cessation in a high percentage (58% to 80% in arteriovenous malformation) of cases, long before the expected treatment of the lesion and sometimes even in spite of failing to cure the lesion itself.

  • Radiotherapeutic treatment of intractable epilepsies with or without space-occupying lesions can lead to a reduction in seizure frequency and/or severity.

  • Experimental models of epilepsies treated with radiation therapy have demonstrated a dose-dependent positive effect of radiation on the frequency and severity of the seizures and on the extent of discharge propagation.


Temporal Lobe Epilepsy Gamma Knife Epilepsy Surgery Intractable Epilepsy Mesial Temporal Lobe Epilepsy 


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Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Jean Régis
    • 1
  • Fabrice Bartolomei
    • 2
  • Patrick Chauvel
    • 2
  1. 1.Departement de Neurochirurgie Centre HospitalierEr Universitaire La TimoneMarseilleFrance
  2. 2.Service de Neurophysiologie CliniqueUniversité de la MéditerranéeMarseilleFrance

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