Radiobiological Principles Underlying Stereotactic Radiation Therapy

  • David J. Brenner


Since the Gamma Knife was first conceived in 1968, primarily for arterial and functional lesions [1], single-fractioned stereotactic radiation therapy* has been increasingly used to treat a variety of cerebral lesions. By 1985, an alternative modality was available for stereotactic radiation therapy, using a linear accelerator (linac) and a stereotactic head frame [4], [5]. Recently, the CyberKnife, a frameless robotic system, has been developed for stereotactic radiation therapy [6], and intensity-modulated stereotactic radiation therapy [7], [8] is now entering clinical practice.


Radiat Oncol Biol Phys Arteriovenous Malformation Gamma Knife Stereotactic Radiosurgery Hypoxic Cell 
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© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • David J. Brenner
    • 1
  1. 1.Center for Radiological Research, Department of Radiation OncologyColumbia University Medical CenterNew YorkUSA

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