Cavernous Malformations and Other Vascular Diseases

  • Ajay Niranjan
  • David Mathieu
  • Douglas Kondziolka
  • John C. Flickinger
  • L. Dade Lunsford


Intracranial cavernous malformations are angiographically occult developmental malformations of the vascular bed. These abnormal vascular connections may enlarge over time. The lesions can occur on a familial basis. Patients may be asymptomatic, although they often present with headaches, seizures, or parenchymal hemorrhages. Substantial advances in the cellular and molecular biology of the vasculogenesis, angiogenesis, and cardiovascular physiology of these anomalies along with findings from detailed clinicopathologic and clinicoradiologic retrospective and prospective longitudinal studies have led to a better understanding of these vascular malformations as a whole.


Cavernous Sinus Gamma Knife Stereotactic Radiosurgery Cavernous Hemangioma Cavernous Malformation 


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Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Ajay Niranjan
    • 1
  • David Mathieu
    • 2
  • Douglas Kondziolka
    • 3
  • John C. Flickinger
    • 2
  • L. Dade Lunsford
    • 2
  1. 1.University of PittsburghPittsburghUSA
  2. 2.Department of Neurological SurgeryUniversity of PittsburghPittsburghUSA
  3. 3.University of PittsburghPittsburghUSA

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