Skip to main content

Abstract

Although spinal neoplasms constitute only a fraction of central nervous system tumors [1], [2], treatment of these lesions remains an important component of neurosurgical practice. The protective function provided by the spinal column requires a tightly confined relationship between complex skeletal anatomy and delicate neuronal structures. As a result, access for tumor removal is often limited, and treatment strategies other than microsurgery are frequently employed. Radiation therapy has become a mainstay in the treatment of both primary [3] and metastatic disease of the spine [4] and spinal cord [5]. Such therapy frequently provides significant palliative benefit and, in rare cases, can even be locally curative.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 229.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Sundaresan N, Boriani S, Rothman A, Holtzman R. Tumors of the osseous spine. J Neurooncol 2004; 69:273–290.

    Article  PubMed  Google Scholar 

  2. Parsa AT, Lee J, Parney IF, et al. Spinal cord and intradural-extraparenchymal spinal tumors: current best care practices and strategies. J Neurooncol 2004; 69:291–318.

    Article  PubMed  Google Scholar 

  3. Ozaki T, Flege S, Liljenqvist U, et al. Osteosarcoma of the spine: experience of the Cooperative Osteosarcoma Study Group. Cancer 2002; 94:1069–1077.

    Article  PubMed  Google Scholar 

  4. Bilsky MH, Lis E, Raizer J, et al. The diagnosis and treatment of metastatic spinal tumor. Oncologist 1999; 4:459–469.

    CAS  PubMed  Google Scholar 

  5. Bowers DC, Weprin BE. Intramedullary spinal cord tumors. Curr Treat Options Neurol 2003; 5:207–212.

    Article  PubMed  Google Scholar 

  6. Kopelson G, Linggood RM, Kleinman GM, et al. Management of intramedullary spinal cord tumors. Radiology 1980; 135:473–479.

    CAS  PubMed  Google Scholar 

  7. McCunniff AJ, Liang MJ. Radiation tolerance of the cervical spinal cord. Int J Radiat Oncol Biol Phys 1989; 16:675–678.

    CAS  PubMed  Google Scholar 

  8. Marcus RB Jr, Million RR. The incidence of myelitis after irradiation of the cervical spinal cord. Int J Radiat Oncol Biol Phys 1990; 19:3–8.

    PubMed  Google Scholar 

  9. Schultheiss TE, Kun LE, Ang KK, Stephens LC. Radiation response of the central nervous system. Int J Radiat Oncol Biol Phys 1995; 31:1093–1112.

    CAS  PubMed  Google Scholar 

  10. Ryu S, Fang Yin F, Rock J, et al. Image-guided and intensity-modulated radiosurgery for patients with spinal metastasis. Cancer 2003; 97:2013–2018.

    Article  PubMed  Google Scholar 

  11. Ryu SI, Chang SD, Kim DH, et al. Image-guided hypofractionated stereotactic radiosurgery to spinal lesions. Neurosurgery 2001; 49:838–846.

    Article  CAS  PubMed  Google Scholar 

  12. Leksell L. The stereotaxic method and radiosurgery of the brain. Acta Chir Scand 1951; 102:316–319.

    CAS  PubMed  Google Scholar 

  13. Woroschiloff C. Der Verlauf der motorishen und senililen Bahnen durch das Lendenmark des Kaninchens. Ber Vehr Sach Ges Wiss Leipzig 1874; 26:248–304.

    Google Scholar 

  14. Rand RW, Bauer RO, Smart CR, Jannetta PJ. Experiences with percutaneous stereotaxic cryocordotomy. Bull Los Angeles Neurol Soc 1965; 30:142–147.

    CAS  PubMed  Google Scholar 

  15. Hitchcock E. An apparatus for stereotactic spinal surgery. Lancet 1969; 1:705–706.

    Article  CAS  PubMed  Google Scholar 

  16. Nadvornik P. Woroschiloff’s locating device for interventions on the spinal cord and its influence on spinal stereotaxis. Appl Neurophysiol 1985; 48:247–251.

    CAS  PubMed  Google Scholar 

  17. Hamilton AJ, Lulu BA, Fosmire H, et al. Preliminary clinical experience with linear accelerator-based spinal stereotactic radiosurgery. Neurosurgery 1995; 36:311–319.

    Article  CAS  PubMed  Google Scholar 

  18. Hamilton AJ, Lulu BA. A prototype device for linear accelerator-based extracranial radiosurgery. Acta Neurochir Suppl 1995; 63:40–43.

    CAS  PubMed  Google Scholar 

  19. Hamilton AJ, Lulu BA, Fosmire H, Gossett L. LINAC-based spinal stereotactic radiosurgery. Stereotact Funct Neurosurg 1996; 66:1–9.

    Article  CAS  PubMed  Google Scholar 

  20. Murphy MJ. An automatic six-degree-of-freedom image registration algorithm for image-guided frameless stereotaxic radiosurgery. Med Phys 1997; 24:857–866.

    Article  CAS  PubMed  Google Scholar 

  21. Adler JR Jr, Chang SD, Murphy MJ, et al. The CyberKnife: a frameless robotic system for radiosurgery. Stereotact Funct Neurosurg 1997; 69:124–128.

    Article  PubMed  Google Scholar 

  22. Chang SD, Main W, Martin DP, et al. An analysis of the accuracy of the CyberKnife: a robotic frameless stereotactic radiosurgical system. Neurosurgery 2003; 52:140–146; discussion 146–147.

    Article  PubMed  Google Scholar 

  23. Chang SD, Meisel JA, Hancock SL, et al. Treatment of hemangioblastomas in von Hippel-Lindau disease with linear accelerator-based radiosurgery. Neurosurgery 1998; 43:28–34; discussion 34–35.

    Article  CAS  PubMed  Google Scholar 

  24. Murphy MJ, Martin D, Whyte R, et al. The effectiveness of breath-holding to stabilize lung and pancreas tumors during radiosurgery. Int J Radiat Oncol Biol Phys 2002; 53:475–482.

    PubMed  Google Scholar 

  25. Murphy MJ, Adler JR Jr, Bodduluri M, et al. Image-guided radiosurgery for the spine and pancreas. Comput Aided Surg 2000; 5:278–288.

    Article  CAS  PubMed  Google Scholar 

  26. Gerszten PC, Ozhasoglu C, Burton SA, et al. Evaluation of CyberKnife frameless real-time image-guided stereotactic radiosurgery for spinal lesions. Stereotact Funct Neurosurg 2003; 81:84–89.

    Article  PubMed  Google Scholar 

  27. Chang SD, Le Q, Martin DP, Adler JR. The CyberKnife. In: Dickman CA, ed. Spinal Cord and Spinal Column Tumors: Principles and Practices. New York: Thieme, 2005.

    Google Scholar 

  28. Gerszten PC, Welch WC. CyberKnife radiosurgery for metastatic spine tumors. Neurosurg Clin N Am 2004; 15:491–501.

    Article  PubMed  Google Scholar 

  29. Rock JP, Ryu S, Yin FF. Novalis radiosurgery for metastatic spine tumors. Neurosurg Clin N Am 2004; 15:503–509.

    Article  PubMed  Google Scholar 

  30. De Salles AA, Pedroso AG, Medin P, et al. Spinal lesions treated with Novalis shaped beam intensity-modulated radiosurgery and stereotactic radiotherapy. J Neurosurg 2004; 101(Suppl 3):435–440.

    PubMed  Google Scholar 

  31. Schick U, Marquardt G, Lorenz R. Recurrence of benign spinal neoplasms. Neurosurg Rev 2001; 24:20–25.

    Article  CAS  PubMed  Google Scholar 

  32. Cohen-Gadol AA, Zikel OM, Koch CA, et al. Spinal meningiomas in patients younger than 50 years of age: a 21-year experience. J Neurosurg Spine 2003; 98:258–263.

    Article  Google Scholar 

  33. Gottfried ON, Gluf W, Quinones-Hinojosa A, et al. Spinal meningiomas: surgical management and outcome. Neurosurg Focus 2003; 14:e2.

    Article  PubMed  Google Scholar 

  34. Conti P, Pansini G, Mouchaty H, et al. Spinal neurinomas: retrospective analysis and long-term outcome of 179 consecutively operated cases and review of the literature. Surg Neurol 2004; 61:34–43; discussion 44.

    Article  PubMed  Google Scholar 

  35. McCormick PC. Surgical management of dumbbell and paraspinal tumors of the thoracic and lumbar spine. Neurosurgery 1996; 38:67–74; discussion 74–75.

    Article  CAS  PubMed  Google Scholar 

  36. McCormick PC. Surgical management of dumbbell tumors of the cervical spine. Neurosurgery 1996; 38:294–300.

    Article  CAS  PubMed  Google Scholar 

  37. Gambardella G, Gervasio O, Zaccone C. [Approaches and surgical results in the treatment of ventral thoracic meningiomas. Review of our experience with a postero-lateral combined transpedicular-transarticular approach.] Acta Neurochir (Wien) 2003; 145:385–392; discussion 392.

    CAS  Google Scholar 

  38. Asazuma T, Toyama Y, Maruiwa H, et al. Surgical strategy for cervical dumbbell tumors based on a three-dimensional classification. Spine 2004; 29:E10–14.

    Article  PubMed  Google Scholar 

  39. Gezen F, Kahraman S, Canakci Z, Beduk A. Review of 36 cases of spinal cord meningioma. Spine 2000; 25:727–731.

    Article  CAS  PubMed  Google Scholar 

  40. Roux FX, Nataf F, Pinaudeau M, et al. Intraspinal meningiomas: review of 54 cases with discussion of poor prognosis factors and modern therapeutic management. Surg Neurol 1996; 46:458–463; discussion 463–464.

    Article  CAS  PubMed  Google Scholar 

  41. Gerszten PC, Ozhasoglu C, Burton SA, et al. CyberKnife frameless single-fraction stereotactic radiosurgery for benign tumors of the spine. Neurosurg Focus 2003; 14:e16.

    Article  PubMed  Google Scholar 

  42. Murphy MJ, Cox RS. The accuracy of dose localization for an image-guided frameless radiosurgery system. Med Phys 1996; 23:2043–2049.

    Article  CAS  PubMed  Google Scholar 

  43. Murphy MJ, Chang SD, Gibbs IC, et al. Patterns of patient movement during frameless image-guided radiosurgery. Int J Radiat Oncol Biol Phys 2003; 55:1400–1408.

    PubMed  Google Scholar 

  44. Kondziolka D, Nathoo N, Flickinger JC, et al. Long-term results after radiosurgery for benign intracranial tumors. Neurosurgery 2003; 53:815–821; discussion 821–822.

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2008 Springer Science+Business Media, LLC

About this chapter

Cite this chapter

Dodd, R.L., Gibbs, I., Adler, J.R., Chang, S.D. (2008). Spinal Tumors. In: Chin, L.S., Regine, W.F. (eds) Principles and Practice of Stereotactic Radiosurgery. Springer, New York, NY. https://doi.org/10.1007/978-0-387-71070-9_43

Download citation

  • DOI: https://doi.org/10.1007/978-0-387-71070-9_43

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-0-387-71069-3

  • Online ISBN: 978-0-387-71070-9

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics