Pineal Region Tumors: Chemotherapy Perspective

  • Barry Meisenberg
  • Lavanya Yarlagadda


Tumors involving the pineal gland are uncommon, accounting for 0.4% to 11% of intracranial tumors in children, and 0.4% to 1% of such tumors in adults [1]. Tumors arising within the pineal gland are commonly of three principal histologic types, each with its own subtypes. It is most appropriate to consider treatment approaches based on the histologic type, not anatomic origin. The three main types of pineal tumors that will be considered are germ cell tumors (GCTs), pineal parenchymal tumors (PPTs), and astrocytomas. Other tumors that are occasionally seen in this area are meningiomas, gangliogliomas, ependymomas, lipomas, and metastatic cancer. Pineal cysts, vascular malformations and aneurysms are benign lesions that can occur in the pineal region, occasionally posing a diagnostic challenge.


Germ Cell Tumor Pineal Gland Pineal Region MGMT Gene Pineal Tumor 
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Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Barry Meisenberg
    • 1
  • Lavanya Yarlagadda
    • 2
  1. 1.Department of MedicineUniversity of Maryland, School of MedicineBaltimoreUSA
  2. 2.Department of MedicineUniversity of MarylandBaltimoreUSA

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