Pediatric Brain Tumors: Chemotherapy Perspective
Advances in the diagnosis and therapy of children diagnosed with brain tumors have led to an improved survival over that of the past decade . Surgery, radiation therapy, and chemotherapy are the three treatment modalities that are used to treat brain tumors in the pediatric age group. With improved survival rate, there is an increased emphasis to use therapeutic modalities that reduce the neurocognitive deficits that are seen in the long-term survivors . Stereotactic radiosurgery (SRS) offers the advantage of treating residual tumor with higher doses of radiation therapy without exposing large areas of the developing brain to potentially damaging radiation therapy. SRS has been used in treating patients with ependymoma, low-grade glioma, medulloblastoma/primitive neuroectodermal tumor (PNET), and craniopharyngioma. SRS has been used for these various histologies at the time of either primary therapy or at the time of recurrence. This chapter will discuss the perspective of chemotherapy and the role of SRS in the therapy of pediatric brain tumors.
KeywordsRadiat Oncol Biol Phys Stereotactic Radiosurgery Pediatric Brain Tumor Primitive Neuroectodermal Tumor Craniospinal Irradiation
Unable to display preview. Download preview PDF.
- 3.CBTRUS US Statistical Report. Primary brain tumors in the United States 1995–1999. Central Brain Tumor Registry of the United States, Hinsdale, IL; 2002.Google Scholar
- 27.Fitzer MM, Linggood RM, Adams J, et al. Combined proton and photon irradiation for craniopharyngioma: long-term results of the early cohort of patients treated at Harvard cyclotron laboratory and Massachusetts General Hospital. Int J Radiat Oncol Biol Phys 2006; 64(5):1348–1354.Google Scholar