Pituitary and Pituitary Region Tumors: Fractionated Radiation Therapy Perspective

  • Jonathan P.S. Knisely
  • Paul W. Sperduto


Fractionated radiotherapy for pituitary tumors and tumors arising in the parasellar region has been used for a century. The multidisciplinary nature of optimal management of tumors of the anterior skull base has been clearly established; the expertise of endocrinologists, neurosurgeons, radiation oncologists, neuroradiologists, neuroophthalmologists, and laboratory medicine specialists are all commonly required to optimally manage tumors that arise in the pituitary or pituitary region. The skull base structures surrounding the pituitary gland are anatomically complex [1]. The proximity of a number of important vascular structures and cranial nerves makes a surgical approach to tumors arising in the pituitary region complex; accordingly, complete resections with acceptable operative morbidity can be difficult to achieve. Iatrogenic damage may occur during the treatment of an anterior skull base tumor that may result in endocrinologic, visual, or other neurologic deficits. Radiation can induce second tumors and cause endocrine insufficiencies. It is easy to appreciate the potential of iatrogenic damage to decrease the quality of life for patients that may live for decades after an intervention.


Optic Nerve Pituitary Adenoma Radiat Oncol Biol Phys Cavernous Sinus Nonfunctional Adenoma 


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Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Jonathan P.S. Knisely
    • 1
    • 2
  • Paul W. Sperduto
    • 3
  1. 1.Department of Therapeutic RadiologyYale University School of MedicineNew HavenUSA
  2. 2.Yale Cancer CenterYale-New Haven HospitalNew HavenUSA
  3. 3.Gamma Knife CenterUniversity of Minnesota Medical CenterMinneapolisUSA

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