Meningioma: Systemic Therapy Perspective

  • Steven Grunberg


Meningiomas pose a dilemma for the oncologist. Although meningiomas are indeed tumors (i.e., abnormal tissue growth), most meningiomas are histologically benign. The morbidity of this condition is generally not related to rapid invasive growth or to metastases, the properties that define malignancies. Instead, symptoms of this condition are primarily due to location. Slow tumor growth in the extremities or trunk can remain asymptomatic and undetected for extended periods of time. Retroperitoneal tumors, such as nonfunctioning adrenocortical carcinoma, can easily reach 10 cm in size before clinical symptoms are apparent [1]. However, there is only a fixed amount of space within the skull. If one structure increases in size, another must give way, usually with the appearance of neurologic symptoms. The proximity of vital neurologic structures can also rapidly lead to complex neurologic deficits while making the physical approach to the tumor mass more difficult. Because meningioma tends to be a localized problem, the use of localized modalities is the logical therapeutic approach, and the use of systemic modalities, which may also result in systemic toxicities, must be adequately justified.


Epidermal Growth Factor Receptor Epidermal Growth Factor Receptor Inhibitor Adrenocortical Carcinoma Meningioma Cell Malignant Meningioma 
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Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Steven Grunberg
    • 1
  1. 1.Department of Medical OncologyBurlingtonUSA

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