Skip to main content
SpringerLink
Log in

Metastatic Brain Tumors: Surgery Perspective

  • Chapter
Principles and Practice of Stereotactic Radiosurgery

Abstract

Metastatic brain tumors occur more frequently than other intracranial neoplasms and are a serious complication of systemic cancer [1]. Their annual incidence exceeds 100,000 [2], [3] and is on the rise as patients live longer from improved treatments for extracranial cancer [4], [5]. Thus, patients with brain metastases constitute a significant fraction of the case load in the neurosurgery services at many oncologic care centers.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 229.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Posner JB, Chernik NL. Intracranial metastases from systemic cancer. Adv Neurol 1978; 19:579–592.

    CAS  PubMed  Google Scholar 

  2. Tsukada Y, Fouad A, Pickren JW, Lane WW. Central nervous system metastasis from breast carcinoma. Autopsy study. Cancer 1983; 52(12):2349–2354.

    Article  CAS  PubMed  Google Scholar 

  3. Sawaya R, Bindal RK, Lang FF, Abi-Said D. Metastatic brain tumors. In: Kaye AH, Laws ER, eds. Brain Tumors: An Encyclopedic Approach, 2nd ed. Edinburgh: Churchill Livingstone, 2001:999–1026.

    Google Scholar 

  4. Sawaya R. Surgical treatment of brain metastases. Clin Neurosurg 1999; 45:41–47.

    CAS  PubMed  Google Scholar 

  5. Young RF. Radiosurgery for the treatment of brain metastases. Semin Surg Oncol 1998; 14(1):70–78.

    Article  CAS  PubMed  Google Scholar 

  6. Grant FC. Concerning intracranial malignant metastases: their frequency and the value of surgery in their treatment. Ann Surg 1926; 84:635–646.

    Article  CAS  PubMed  Google Scholar 

  7. Cairncross JG, Posner JB. The management of brain metastases. In: Walker MD, ed. Oncology of the Nervous System. Boston: Martinus Nijhof, 1983:341–377.

    Google Scholar 

  8. Horwitz NH, Rizzoli HV. Postoperative complications of intracranial neurological surgery. Baltimore: Williams & Wilkins, 1982.

    Google Scholar 

  9. Borgelt B, Gelber R, Kramer S, et al. The palliation of brain metastases: final results of the first two studies by the Radiation Therapy Oncology Group. Int J Radiat Oncol Biol Phys 1980; 6(1):1–9.

    CAS  PubMed  Google Scholar 

  10. Diener-West M, Dobbins TW, Phillips TL, Nelson DF. Identification of an optimal subgroup for treatment evaluation of patients with brain metastases using RTOG study 7916. Int J Radiat Oncol Biol Phys 1989; 16(3):669–673.

    CAS  PubMed  Google Scholar 

  11. Sneed PK, Larson DA, Wara WM. Radiotherapy for cerebral metastases. Neurosurg Clin N Am 1996; 7(3):505–515.

    CAS  PubMed  Google Scholar 

  12. Noordijk EM, Vecht CJ, Haaxma-Reiche H, et al. The choice of treatment of single brain metastasis should be based on extracranial tumor activity and age. Int J Radiat Oncol Biol Phys 1994; 29(4):711–717.

    CAS  PubMed  Google Scholar 

  13. Patchell RA, Tibbs PA, Walsh JW, et al. A randomized trial of surgery in the treatment of single metastases to the brain. N Engl J Med 1990; 322(8):494–500.

    CAS  PubMed  Google Scholar 

  14. Leksell L. The stereotaxic method and radiosurgery of the brain. Acta Chir Scand 1951; 102:316.

    CAS  PubMed  Google Scholar 

  15. Leksell L. Stereotactic radiosurgery. J Neurol Neurosurg Psychiatry 1983; 46(9):797–803.

    Article  CAS  PubMed  Google Scholar 

  16. Auchter RM, Lamond JP, Alexander E, et al. A multiinstitutional outcome and prognostic factor analysis of radiosurgery for resectable single brain metastasis. Int J Radiat Oncol Biol Phys 1996; 35(1):27–35.

    CAS  PubMed  Google Scholar 

  17. Flickinger JC, Kondziolka D. Radiosurgery instead of resection for solitary brain metastasis: the gold standard redefined [editorial] [see comments]. Int J Radiat Oncol Biol Phys 1996; 35(1):185–186.

    Article  CAS  PubMed  Google Scholar 

  18. Hasegawa T, Kondziolka D, Flickinger JC, et al. Brain metastases treated with radiosurgery alone: an alternative to whole brain radiotherapy? Neurosurgery 2003; 52(6):1318–1326; discussion 1326.

    Article  PubMed  Google Scholar 

  19. Lutterbach J, Cyron D, Henne K, Ostertag CB. Radiosurgery followed by planned observation in patients with one to three brain metastases. Neurosurgery 2003; 52(5):1066–1073; discussion 1073–1074.

    Article  PubMed  Google Scholar 

  20. Sneed PK, Suh JH, Goetsch SJ, et al. A multi-institutional review of radiosurgery alone vs. radiosurgery with whole brain radiotherapy as the initial management of brain metastases. Int J Radiat Oncol Biol Phys 2002; 53(3):519–526.

    PubMed  Google Scholar 

  21. Bindal RK, Sawaya R, Leavens ME, Lee JJ. Surgical treatment of multiple brain metastases. J Neurosurg 1993; 79(2):210–216.

    Article  CAS  PubMed  Google Scholar 

  22. Bindal RK, Sawaya R, Leavens ME, et al. Reoperation for recurrent metastatic brain tumors. J Neurosurg 1995; 83(4):600–604.

    Article  CAS  PubMed  Google Scholar 

  23. Bindal AK, Bindal RK, Hess KR, et al. Surgery versus radiosurgery in the treatment of brain metastasis. J Neurosurg 1996; 84(5):748–754.

    Article  CAS  PubMed  Google Scholar 

  24. Dare AO, Sawaya R. Part II: Surgery versus radiosurgery for brain metastasis: surgical advantages and radiosurgical myths. Clin Neurosurg 2004; 51:255–263.

    PubMed  Google Scholar 

  25. Mehta MP, Rozental JM, Levin AB, et al. Defining the role of radiosurgery in the management of brain metastases. Int J Radiat Oncol Biol Phys 1992; 24(4):619–625.

    CAS  PubMed  Google Scholar 

  26. Chang EL, Hassenbusch SJ 3rd, Shiu AS, et al. The role of tumor size in the radiosurgical management of patients with ambiguous brain metastases. Neurosurgery 2003; 53(2):272–280.

    Article  PubMed  Google Scholar 

  27. Regine WF, Huhn JL, Patchell RA, et al. Risk of symptomatic brain tumor recurrence and neurologic deficit after radiosurgery alone in patients with newly diagnosed brain metastases: results and implications. Int J Radiat Oncol Biol Phys 2002; 52(2):333–338.

    PubMed  Google Scholar 

  28. Selek U, Chang EL, Hassenbusch SJ 3rd, et al. Stereotactic radiosurgical treatment in 103 patients for 153 cerebral melanoma metastases. Int J Radiat Oncol Biol Phys 2004; 59(4):1097–1106.

    Article  PubMed  Google Scholar 

  29. Kondziolka D, Patel A, Lunsford LD, Kassam A, Flickinger JC. Stereotactic radiosurgery plus whole brain radiotherapy versus radiotherapy alone for patients with multiple brain metastases. Int J Radiat Oncol Biol Phys 1999; 45(2):427–434.

    CAS  PubMed  Google Scholar 

  30. Shehata MK, Young B, Reid B, et al. Stereotatic radiosurgery of 468 brain metastases ≤ 2 cm: implications for SRS dose and whole brain radiation therapy. Int J Radiat Oncol Biol Phys 2004; 59(1):87–93.

    PubMed  Google Scholar 

  31. Cho KH, Hall WA, Lee AK, et al. Stereotactic radiosurgery for patients with single brain metastasis. J Radiosurg 1998; 1(2):79–85.

    Article  Google Scholar 

  32. O’Neill BP, Iturria NJ, Link MJ, et al. A comparison of surgical resection and stereotactic radiosurgery in the treatment of solitary brain metastases. Int J Radiat Oncol Biol Phys 2003; 55(5):1169–1176.

    PubMed  Google Scholar 

  33. Vecil GG, Suki D, Maldaun MV, et al. Resection of brain metastases previously treated with stereotactic radiosurgery. J Neurosurg 2005; 102(2):209–215.

    Article  PubMed  Google Scholar 

  34. Alexander E 3rd, Moriarty TM, Davis RB, et al. Stereotactic radiosurgery for the definitive, noninvasive treatment of brain metastases. J Natl Cancer Inst 1995; 87(1):34–40.

    Article  PubMed  Google Scholar 

  35. Flickinger JC, Kondziolka D, Lunsford LD, et al. A multiinstitutional experience with stereotactic radiosurgery for solitary brain metastasis. Int J Radiat Oncol Biol Phys 1994; 28(4):797–802.

    CAS  PubMed  Google Scholar 

  36. Kihlstrom L, Karlsson B, Lindquist C, et al. Gamma knife surgery for cerebral metastasis. Acta Neurochir Suppl (Wien) 1991; 52:87–89.

    CAS  Google Scholar 

  37. Muacevic A, Kreth FW, Horstmann GA, et al. Surgery and radiotherapy compared with gamma knife radiosurgery in the treatment of solitary cerebral metastases of small diameter. J Neurosurg 1999; 91(1):35–43.

    Article  CAS  PubMed  Google Scholar 

  38. Petrovich Z, Yu C, Giannotta SL, et al. Survival and pattern of failure in brain metastasis treated with stereotactic gamma knife radiosurgery. J Neurosurg 2002; 97(5 Suppl):499–506.

    PubMed  Google Scholar 

  39. Voorhies RM, Sundaresan N, Thaler HT. The single supratentorial lesion. An evaluation of preoperative diagnostic tests. J Neurosurg 1980; 53(3):364–368.

    Article  CAS  PubMed  Google Scholar 

  40. Mehta M, Noyes W, Craig B, et al. A cost-effectiveness and costutility analysis of radiosurgery vs. resection for single-brain metastases. Int J Radiat Oncol Biol Phys 1997; 39(2):445–454.

    CAS  PubMed  Google Scholar 

  41. Rutigliano MJ, Lunsford LD, Kondziolka D, et al. The cost effectiveness of stereotactic radiosurgery versus surgical resection in the treatment of solitary metastatic brain tumors. Neurosurgery 1995; 37(3):445–453; discussion 453–455.

    Article  CAS  PubMed  Google Scholar 

  42. Loeffler JS, Alexander E 3rd. Radiosurgery for the treatment of intracranial metastases. In: Alexander E 3rd, Loeffler JS, Lunsford LD, eds. Stereotactic Radiosurgery. New York: McGraw-Hill, 1993:197–206.

    Google Scholar 

  43. Sturm V, Kimmig B, Engenhardt R, et al. Radiosurgical treatment of cerebral metastases. Method, indications and results. Stereotact Funct Neurosurg 1991; 57(1–2):7–10.

    Article  CAS  PubMed  Google Scholar 

  44. Kondziolka D, Lunsford LD. Brain metastases. In: Apuzzo MLJ, ed. Brain Surgery: Complication Avoidance and Management. New York: Churchill Livingstone, 1993:615–641.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Neurosurgery, University of Texas M.D. Anderson Cancer Center, Houston, TX, USA

    Raymond Sawaya MD (Professor and Chairman) & David M. Wildrick PhD (Surgery Publications Coordinator)

Authors
  1. Raymond Sawaya MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. David M. Wildrick PhD
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Neurosurgery, Boston University School of Medicine, Boston, MA, USA

    Lawrence S. Chin MD (Professor and Chairman) (Professor and Chairman)

  2. Department of Radiation Oncology, University of Maryland Medical School, Baltimore, MD, USA

    William F. Regine MD (Professor and Chairman) (Professor and Chairman)

Rights and permissions

Reprints and permissions

Copyright information

© 2008 Springer Science+Business Media, LLC

About this chapter

Cite this chapter

Sawaya, R., Wildrick, D.M. (2008). Metastatic Brain Tumors: Surgery Perspective. In: Chin, L.S., Regine, W.F. (eds) Principles and Practice of Stereotactic Radiosurgery. Springer, New York, NY. https://doi.org/10.1007/978-0-387-71070-9_15

Download citation

  • DOI: https://doi.org/10.1007/978-0-387-71070-9_15

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-0-387-71069-3

  • Online ISBN: 978-0-387-71070-9

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation