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Proton Beam Radiosurgery: Physical Bases and Clinical Experience

  • Georges Noel
  • Markus Fitzek
  • Loïc Feuvret
  • Jean Louis Habrand

Abstract

The introduction of photon therapy into the armamentarium of cancer treatment represented a breakthrough in the early 20th century. Since then, major technical innovations in radiation oncology have been continuously associated with major improvements in local tumor control and patient quality of life. The development of computer technology two decades ago allowed an unprecedented step forward with the design of computer-driven linear accelerators, multileaf collimation, threedimensional treatment planning, and intensity modulation of the beam. In parallel, biological concepts on tumor control probability have been modeled and studied in relation to tumor volume, clonogens sensitivity, biological environment, and so forth. A basic concept remained, however; that is, the probability of local and to some extent distant control are dose-correlated to the primary tumor. This gave the impetus to the exploration of new forms of particles, especially the “biologically” effective ones, like neutrons. In our opinion, disappointing results in this field should not discourage, but rather pave avenues to new investigations, dealing with heavy ions for example. An alternative approach is based on purely “ballistically” effective particles, with protons as a paradigm.

Keywords

Overall Survival Skull Base Proton Beam Radiat Oncol Biol Phys Uveal Melanoma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Orecchia R, Zurlo A, Loasses A, et al. Particle beam therapy (hadron therapy): basis for interest and clinical experience. Eur J Cancer 1998; 34:459–468.PubMedCrossRefGoogle Scholar
  2. 2.
    Bragg WH, Kleeman R. On the alpha particles of radium, and their loss of range in passing through various atoms and molecules. Philos Mag 1905; S6:318–340.Google Scholar
  3. 3.
    Wilson RR. Radiological use of fast proton. Radiology 1946; 47:487–491.PubMedGoogle Scholar
  4. 4.
    Wilson R. A Brief History of the Harvard University Cyclotrons. Cambridge, MA: Harvard University Department of Physics, 2004.Google Scholar
  5. 5.
    Kjellberg RN, Hanamura T, Davis KR, et al. Bragg-peak protonbeam therapy for arteriovenous malformations of the brain. N Engl J Med 1983; 309:269–274.PubMedGoogle Scholar
  6. 6.
    Urano M, Verhey LJ, Goitein M, et al. Relative biological effectiveness of modulated proton beams in various murine tissues. Int J Radiat Oncol Biol Phys 1984; 10:509–514.PubMedGoogle Scholar
  7. 7.
    Brown A, Suit H. The centery of the discovery of the Bragg peak. Int J Radiat Oncol Biol Phys 2004; 73:268.Google Scholar
  8. 8.
    Goitein G, Lomax A, Pedroni ES. Treating cancer with protons. Physics Today 2002; 45–55.Google Scholar
  9. 9.
    Moyers MF, Lesyna W. Isocenter characteristics of an external ring proton gantry. Int J Radiat Oncol Biol Phys 2004; 60:1622–1630.PubMedGoogle Scholar
  10. 10.
    Tourovsky A, Lomax AJ, Schneider U, Pedroni E. Monte Carlo dose calculations for spot scanned proton therapy. Phys Med. Biol 2005; 50:971–981.PubMedCrossRefGoogle Scholar
  11. 11.
    Chu WT, Ludewigt BA, Renner TR. Instrumentation for treatment of cancer using proton and light-ion beams. Rev Sci Instrum 1993; 64:2055–2122.CrossRefGoogle Scholar
  12. 12.
    Paganetti H, Niemierko A, Ancukiewicz M, et al. Relative biological effectiveness (RBE) values for proton beam therapy. Int J Radiat Oncol Biol Phys 2002; 53:407–421.PubMedGoogle Scholar
  13. 13.
    Molokanov AG, Spurny F. Biological weighted effective dose in 205 MeV clinical proton beam. Phys Med Biol 2005; 50:281–287.PubMedCrossRefGoogle Scholar
  14. 14.
    Delacroix S, Bridier A, Mazal A, et al. Proton dosimetry comparison involving ionometry and calorimetry. Int J Radiat Oncol Biol Phys 1997; 37:711–718.PubMedGoogle Scholar
  15. 15.
    Archambeau JO, Slater JD, Slater JM, Tangeman R. Role for proton beam irradiation in treatment of pediatric CNS malignancies. Int J Radiat Oncol Biol Phys 1992; 22:287–294.PubMedGoogle Scholar
  16. 16.
    Fitzek MM, Thornton AF, Rabinov JD, et al. Accelerated fractionated proton/photon irradiation to 90 cobalt gray equivalent for glioblastoma multiforme: results of a phase II prospective trial. J Neurosurg 1999; 91:251–260.PubMedCrossRefGoogle Scholar
  17. 17.
    Fitzek MM, Thornton AF, Harsh G, et al. Dose-escalation with proton/photon irradiation for Daumas-Duport lower-grade glioma: results of an institutional phase I/II trial. Int J Radiat Oncol Biol Phys 2001; 51:131–137.PubMedGoogle Scholar
  18. 18.
    Habrand JL, Mammar H, Ferrand R, et al. Proton beam therapy (PT) in the management of CNS tumors in childhood. Strahlenther Onkol 1999; 175(Suppl 2):91–94.PubMedCrossRefGoogle Scholar
  19. 19.
    Hug EB, Slater JD. Proton radiation therapy for pediatric malignancies: status report. Strahlenther Onkol 1999; 175(Suppl 2):89–91.PubMedCrossRefGoogle Scholar
  20. 20.
    Hug EB, Muenter MW, Adams JA, et al. 3-D-conformal radiation therapy for pediatric giant cell tumors of the skull base. Strahlenther Onkol 2002; 178:239–244.PubMedCrossRefGoogle Scholar
  21. 21.
    Hug EB, Muenter MW, Archambeau JO, et al. Conformal proton radiation therapy for pediatric low-grade astrocytomas. Strahlenther Onkol 2002; 178:10–17.PubMedCrossRefGoogle Scholar
  22. 22.
    Noel G, Habrand IL, Jauffret, de Crevoisier. Radiation therapy for chordoma and chondrosarcoma of the base of the skull and the cervical spine: prognostic factors and patterns of failure. Strahlenther Onkol 2003; 179:241–248.PubMedCrossRefGoogle Scholar
  23. 23.
    Noel G, Feuvret L, Ferrand R, et al. Radiotherapeutic factors in the management of cervical-basal chordomas and chondrosarcomas. Neurosurgery 2004; 55:1252–1260.PubMedGoogle Scholar
  24. 24.
    Wenkel E, Thornton AF, Finkelstein D, et al. Benign meningioma: partially resected, biopsied, and recurrent intracranial tumors treated with combined proton and photon radiotherapy. Int J Radiat Oncol Biol Phys 2000; 48:1363–1370.PubMedGoogle Scholar
  25. 25.
    Tatsuzaki H, Urie MM, Linggood R. Comparative treatment planning: proton vs. x-ray beams against glioblastoma multiforme. Int J Radiat Oncol Biol Phys 1992; 22:265–273.PubMedGoogle Scholar
  26. 26.
    Wambersie A, Gregroire V, Brucher JM. Potential clinical gain of proton (and heavy ion) beams for brain tumors in children. Int J Radiat Oncol Biol Phys 1992; 22:275–286.PubMedGoogle Scholar
  27. 27.
    Amin-Hanjani S, Ogilvy CS, Candia GJ, et al. Stereotactic radiosurgery for cavernous malformations: Kjellberg’s experience with proton beam therapy in 98 cases at the Harvard Cyclotron. Neurosurgery 1998; 42:1229–1236.PubMedCrossRefGoogle Scholar
  28. 28.
    Miralbell R, Crowell C, Suit HD. Potential improvement of three dimension treatment planning and proton therapy in the outcome of maxillary sinus cancer. Int J Radiat Oncol Biol Phys 1992; 22:305–310.PubMedGoogle Scholar
  29. 29.
    Steinberg GK, Fabrikant JI, Marks MP, et al. Stereotactic heavycharged-particle Bragg-peak radiation for intracranial arteriovenous malformations. N Engl J Med 1990; 323:96–101.PubMedCrossRefGoogle Scholar
  30. 30.
    Vernimmen FJ, Slabbert JP, Wilson JA, et al. Stereotactic proton beam therapy for intracranial arteriovenous malformations. Int J Radiat Oncol Biol Phys 2005; 62:44–52.PubMedCrossRefGoogle Scholar
  31. 31.
    Lin R, Hug EB, Schaefer RA, et al. Conformal proton radiation therapy of the posterior fossa: a study comparing protons with three-dimensional planned photons in limiting dose to auditory structures. Int J Radiat Oncol Biol Phys 2000; 48:1219–1226.PubMedCrossRefGoogle Scholar
  32. 32.
    Miralbell R, Lomax A, Russo M. Potential role of proton therapy in the treatment of pediatric medulloblastoma/primitive neuroectodermal tumors: spinal theca irradiation. Int J Radiat Oncol Biol Phys 1997; 38:805–811.PubMedCrossRefGoogle Scholar
  33. 33.
    Slater JD, Yonemoto LT, Mantik DW, et al. Proton radiation for treatment of cancer of the oropharynx: Early experience at Loma Linda University Medical Center using a concomitant boost technique. Int J Radiat Oncol Biol Phys 2005; 62:494–500.PubMedGoogle Scholar
  34. 34.
    Slater JM, Slater JD, Archambeau JO. Carcinoma of the tonsillar region: potential for use of proton beam therapy. Int J Radiat Oncol Biol Phys 1992; 22:311–319.PubMedGoogle Scholar
  35. 35.
    Brown AP, Urie MM, Chisin R, Suit HD. Proton therapy for carcinoma of the nasopharynx: a study in comparative treatment planning. Int J Radiat Oncol Biol Phys 1989; 16:1607–1614.PubMedGoogle Scholar
  36. 36.
    Lin R, Slater JD, Yonemoto LT, et al. Nasopharyngeal carcinoma: repeat treatment with conformal proton therapy-dose-volume histogram analysis. Radiology 1999; 213:489–494.PubMedGoogle Scholar
  37. 37.
    Noel G, Boisserie G, Dessard-Diana B, et al. Comparaison par les histogrammes dose-volume de deux techniques d’irradiation conformationnelle des cancers du nasopharynx classés T4N0M0: l’une par photons et protons et l’sautre par photons seuls. Cancer Radiother 2002; 6:337–348.PubMedGoogle Scholar
  38. 38.
    Sugahara S, Tokuuye K, Okumura T, et al. Clinical results of proton beam therapy for cancer of the esophagus. Int J Radiat Oncol Biol Phys 2005; 61:76–84.PubMedGoogle Scholar
  39. 39.
    Tsunemoto H, Ishikawa T, Morita S, et al. Indications of particle radiation therapy in the treatment of carcinoma of the esophagus. Int J Radiat Oncol Biol Phys 1992; 22:321–324.PubMedGoogle Scholar
  40. 40.
    Sandler HM, McShan DL, Lichter AS. Potential improvement in the results of irradiation for prostate carcinoma using improved dose distribution. Int J Radiat Oncol Biol Phys 1992; 22:361–367.PubMedGoogle Scholar
  41. 41.
    Schulte RW, Slater JD, Rossi CJ Jr, Slater JM. Value and perspectives of proton radiation therapy for limited stage prostate cancer. Strahlenther Onkol 2000; 176:3–8.PubMedCrossRefGoogle Scholar
  42. 42.
    Isacsson U, Montelius A, Jung B, Glimelius B. Comparative treatment planning between proton and X-ray therapy in locally advanced rectal cancer. Radiother Oncol 1996; 41:263–272.PubMedCrossRefGoogle Scholar
  43. 43.
    Tatsuzaki H, Urie MM, Willett CG. 3-D comparative study of proton vs. x-ray radiation therapy for rectal cancer. Int J Radiat Oncol Biol Phys 1992; 22:369–374.PubMedGoogle Scholar
  44. 44.
    Levin CV. Potential for gain in the use of proton beam boost to the para-aortic lymph nodes in carcinoma of the cervix. Int J Radiat Oncol Biol Phys 1992; 22:355–359.PubMedGoogle Scholar
  45. 45.
    Slater JD, Slater JM, Wahlen S. The potential for proton beam therapy in locally advanced carcinoma of the cervix. Int J Radiat Oncol Biol Phys 1992; 22:343–347.PubMedGoogle Scholar
  46. 46.
    Smit BM. Prospects for proton therapy in carcinoma of the cervix. Int J Radiat Oncol Biol Phys 1992; 22:349–353.PubMedGoogle Scholar
  47. 47.
    Gademann G, Wannenmacher M. Charged particle therapy to pediatric tumors of the retroperitoneal region: a possible indication. Int J Radiat Oncol Biol Phys 1992; 22:375–381.PubMedGoogle Scholar
  48. 48.
    Bush DA, Slater JD, Bonnet R, et al. Proton-beam radiotherapy for early-stage lung cancer. Chest 1999; 116:1313–1319.PubMedCrossRefGoogle Scholar
  49. 49.
    Kawashima M, Furuse J, Nishio T, et al. Phase II study of radiotherapy employing proton beam for hepatocellular carcinoma. J Clin Oncol 2005; 23:1839–1846.PubMedCrossRefGoogle Scholar
  50. 50.
    Gragoudas ES, Marie LA. Uveal melanoma: proton beam irradiation. Ophthalmol Clin North Am 2005; 18:111–118.PubMedCrossRefGoogle Scholar
  51. 51.
    Seddon JM, Gragoudas ES, Albert DM, et al. Comparison of survival rates for patients with uveal melanoma after treatment with proton beam irradiation or enucleation. Am J Ophthalmol 1985; 99:282–290.PubMedGoogle Scholar
  52. 52.
    Munzenrider J, Gragoudas E, Walsh S. conservative treatment of uveal melanoma: survival, local control, eye retention, and vision in patients with intermediate and large tumor after proton beam therapy. Int J Radiat Oncol Biol Phys 1994; 30(Suppl 1):233.Google Scholar
  53. 53.
    Egger E, Schalenbourg A, Zografos L, et al. Maximizing local tumor control and survival after proton beam radiotherapy of uveal melanoma. Int J Radiat Oncol Biol Phys 2001;51:138–147.PubMedGoogle Scholar
  54. 54.
    Courdi A, Caujolle JP, Grange JD, et al. Results of proton therapy of uveal melanomas treated in Nice. Int J Radiat Oncol Biol Phys 1999; 45:5–11.PubMedGoogle Scholar
  55. 55.
    Lumbroso L, Levy C, Plancher C, et al. [Results of proton beam irradiation for treatment of choroidal melanoma]. J Fr Ophtalmol 2002; 25:290–297.PubMedGoogle Scholar
  56. 56.
    Damato B, Kacperek A, Chopra M, et al. Proton beam radiotherapy of choroidal melanoma: the Liverpool-Clatterbridge experience. Int J Radiat Oncol Biol Phys 2005; 62:1405–1411.PubMedGoogle Scholar
  57. 57.
    Damato B, Kacperek A, Chopra M, et al. Proton beam radiotherapy of iris melanoma. Int J Radiat Oncol Biol Phys 2005; 63:109–115.PubMedGoogle Scholar
  58. 58.
    Gragoudas ES, Lane AM, Regan S, et al. A randomized controlled trial of varying radiation doses in the treatment of choroidal melanoma. Arch Ophthalmol 2000; 118:773–778.PubMedGoogle Scholar
  59. 59.
    Weber DC, Bogner J, Verwey J, et al. Proton beam radiotherapy versus fractionated stereotactic radiotherapy for uveal melanomas: a comparative study. Int J Radiat Oncol Biol Phys 2005; 63:373–384.PubMedGoogle Scholar
  60. 60.
    Frau E, Rumen F, Noel G,. Low-dose proton beam therapy for circumscribed choroidal hemangiomas. Arch Ophthalmol 2004; 122:1471–1475.PubMedCrossRefGoogle Scholar
  61. 61.
    Tsina EK, Lane AM, Zacks DN, et al. Treatment of metastatic tumors of the choroid with proton beam irradiation. Ophthalmology 2005; 112:337–343.PubMedCrossRefGoogle Scholar
  62. 62.
    Desjardins L, Levy C, D’hermies F, et al. [Initial results of proton therapy in choroidal melanoma at the d’Orsey Center for Proton Therapy; the first 464 cases]. Cancer Radiother 1997; 1:222–226.PubMedGoogle Scholar
  63. 63.
    Saito K, Unni KK, Wollan PC, Lund BA. Chondrosarcoma of the jaw and facial bones. Cancer 1995; 76:1550–1558.PubMedCrossRefGoogle Scholar
  64. 64.
    Benk V, Liebsch NJ, Munzenrider JE, et al. Base of skull and cervical spine chordomas in children treated by high-dose irradiation. Int J Radiat Oncol Biol Phys 1995; 31:577–581.PubMedGoogle Scholar
  65. 65.
    Munzenrider JE, Liebsch NJ. Proton therapy for tumors of the skull base. Strahlenther Onkol 1999; 175(Suppl 2):57–63.PubMedCrossRefGoogle Scholar
  66. 66.
    Noel G, Feuvret L, Calugaru V, et al. Chordomas of the base of the skull and upper cervical spine. One hundred patients irradiated by a 3D conformal technique combining photon and proton beams. Acta Oncol 2005; 44(7):700–708.PubMedCrossRefGoogle Scholar
  67. 67.
    Igaki H, Tokuuye K, Okumura T, et al. Clinical results of proton beam therapy for skull base chordoma. Int J Radiat Oncol Biol Phys 2004; 60:1120–1126.PubMedGoogle Scholar
  68. 68.
    Weber DC, Rutz HP, Pedroni E, et al. Results of spot scanning proton radiation therapy for chordoma and chondrosarcoma of the skull base: the Paul Scherrer institut experience. Int J Radiat Oncol Biol Phys 2005; 63:401–409.PubMedGoogle Scholar
  69. 69.
    Baumert BG, Lomax AJ, Miltchev V, Davis JB. A comparison of dose distributions of proton and photon beams in stereotactic conformal radiotherapy of brain lesions. Int J Radiat Oncol Biol Phys 2001; 49:1439–1449.PubMedGoogle Scholar
  70. 70.
    Lomax AJ, Bortfeld T, Goitein G, et al. A treatment planning inter-comparison of proton and intensity modulated photon radiotherapy. Radiother Oncol 1999; 51:257–271.PubMedCrossRefGoogle Scholar
  71. 71.
    Fuller DB, Bloom JG. Radiotherapy for chordoma. Int J Radiat Oncol Biol Phys 1988; 15:331–339.PubMedGoogle Scholar
  72. 72.
    Keisch ME, Garcia DM, Shibuya RB. Retrospective long-term follow-up analysis in 21 patients with chordomas of various sites treated at a single institution. J Neurosurg 1991; 75:374–377.PubMedCrossRefGoogle Scholar
  73. 73.
    Romero J, Cardenes H, la Torre A, et al. Chordoma: results of radiation therapy in eighteen patients. Radiother Oncol 1993; 29:27–32.PubMedCrossRefGoogle Scholar
  74. 74.
    Forsyth PA, Cascino TL, Shaw EG, et al. Intracranial chordomas: a clinicopathological and prognostic study of 51 cases. J Neurosurg 1993; 78:741–747.PubMedCrossRefGoogle Scholar
  75. 75.
    Gay E, Sekhar LN, Rubinstein E, et al. Chordomas and chondrosarcomas of the cranial base: results and follow-up of 60 patients. Neurosurgery 1995; 36:887–896.PubMedCrossRefGoogle Scholar
  76. 76.
    Mark RJ, Tran LM, Sercarz J, et al. Chondrosarcoma of the head and neck. The UCLA experience, 1955–1988. Am J Clin Oncol 1993; 16:232–237.PubMedCrossRefGoogle Scholar
  77. 77.
    Ruark DS, Schlehaider UK, Shah JP. Chondrosarcomas of the head and neck. World J Surg 1992; 16:1010–1015.PubMedCrossRefGoogle Scholar
  78. 78.
    Austin-Seymour M, Munzenrider J, Goitein M, et al. Fractionated proton radiation therapy of chordoma and low-grade chondrosarcoma of the base of the skull. J Neurosurg 1989; 70:13–17.PubMedCrossRefGoogle Scholar
  79. 79.
    Hug EB, Loredo LN, Slater JD, et al. Proton radiation therapy for chordomas and chondrosarcomas of the skull base. J Neurosurg 1999; 91:432–439.PubMedCrossRefGoogle Scholar
  80. 80.
    Hug EB, Slater JD. Proton radiation therapy for chordomas and chondrosarcomas of the skull base. Neurosurg Clin N Am 2000; 11:627–638.PubMedGoogle Scholar
  81. 81.
    Noel G, Habrand JL, Mammar H, et al. Combination of photon and proton radiation therapy for chordomas and chondrosarcomas of the skull base: the Centre de Protontherapie D’Orsay experience. Int J Radiat Oncol Biol Phys 2001; 51:392–398.PubMedGoogle Scholar
  82. 82.
    Suit HD, Goitein M, Munzenrider J, et al. Definitive radiation therapy for chordoma and chondrosarcoma of base of skull and cervical spine. J Neurosurg 1982; 56:377–385.PubMedCrossRefGoogle Scholar
  83. 83.
    Austin JP, Urie MM, Cardenosa G, Munzenrider JE. Probable causes of recurrence in patients with chordoma and chondrosarcoma of the base of skull and cervical spine. Int J Radiat Oncol Biol Phys 1993; 25:439–444.PubMedGoogle Scholar
  84. 84.
    Muthukumar N, Kondziolka D, Lunsford LD, Flickinger JC. Stereotactic radiosurgery for chordoma and chondrosarcoma: further experiences. Int J Radiat Oncol Biol Phys 1998; 41:387–392.PubMedGoogle Scholar
  85. 85.
    Halperin EC. Why is female sex an independent predictor of shortened overall survival after proton/photon radiation therapy for skull base chordomas? Int J Radiat Oncol Biol Phys 1997; 38:225–230.PubMedGoogle Scholar
  86. 86.
    Terahara A, Niemierko A, Goitein M, et al. Analysis of the relationship between tumor dose inhomogeneity and local control in patients with skull base chordoma. Int J Radiat Oncol Biol Phys 1999; 45:351–358.PubMedGoogle Scholar
  87. 87.
    Hug EB, Fitzek MM, Liebsch NJ, Munzenrider JE. Locally challenging osteo-and chondrogenic tumors of the axial skeleton: results of combined proton and photon radiation therapy using three-dimensional treatment planning. Int J Radiat Oncol Biol Phys 1995; 31:467–476.PubMedGoogle Scholar
  88. 88.
    Casali PG, Messina A, Stacchiotti S, et al. Imatinib mesylate in chordoma. Cancer 2004; 101:2086–2097.PubMedCrossRefGoogle Scholar
  89. 89.
    Gudjonsson O, Blomquist E, Nyberg G, et al. Stereotactic irradiation of skull base meningiomas with high energy protons. Acta Neurochir (Wien) 1999; 141:933–940.CrossRefGoogle Scholar
  90. 90.
    Austin-Seymour M, Munzenrider J, Linggood R, et al. Fractionated proton radiation therapy of cranial and intracranial tumors. Am J Clin Oncol 1990; 13:327–330.PubMedCrossRefGoogle Scholar
  91. 91.
    Miralbell R, Linggood RM, De La MS, et al. The role of radiotherapy in the treatment of subtotally resected benign meningiomas. J Neurooncol 1992; 13:157–164.PubMedCrossRefGoogle Scholar
  92. 92.
    Noel G, Mammar H, Ferrand R, et al. Résultats de l’irradiation par association de photons et de protons de 47 chordomes et chondrosarcomes et de 17 méningiomes. Expérience du Centre de Protonthérapie d’Orsay. Rev Neurol (Paris) 2002; 158:497–509.Google Scholar
  93. 93.
    Hug EB, DeVries A, Thornton AF, et al. Management of atypical and malignant meningiomas: role of high-dose, 3D-conformal radiation therapy. J Neurooncol 2000; 48:151–160.PubMedCrossRefGoogle Scholar
  94. 94.
    Noel G, Bollet MA, Calugaru V, et al. Functional outcome of patients with benign meningioma treated by 3D conformal irradiation with a combination of photons and protons. Int J Radiat Oncol Biol Phys 2005; 62:1412–1422.PubMedGoogle Scholar
  95. 95.
    Noel G, Habrand IL, Mammar H, et al. Highly conformal therapy using proton component in the management of meningiomas: preliminary experience of the centre de protonthérapie d’Orsay. Strahlenther Onkol 2002; 178:480–485.PubMedCrossRefGoogle Scholar
  96. 96.
    Blomquist E, Carlsson J. Strategy for planned radiotherapy of malignant gliomas: postoperative treatment with combinations of high dose proton irradiation and tumor seeking radionuclides. Int J Radiat Oncol Biol Phys 1992; 22:259–263.PubMedGoogle Scholar
  97. 97.
    Seifert V, Stolke D, Mehdorn HM, Hoffmann B. Clinical and radiological evaluation of long-term results of stereotactic proton beam radiosurgery in patients with cerebral arteriovenous malformations. J Neurosurg 1994; 81:683–689.PubMedCrossRefGoogle Scholar
  98. 98.
    Verhey LJ, Smith V, Serago CF. Comparison of radiosurgery treatment modalities based on physical dose distributions. Int J Radiat Oncol Biol Phys 1998; 40:497–505.PubMedGoogle Scholar
  99. 99.
    Harsh GR, Thornton AF, Chapman PH, et al. Proton beam stereotactic radiosurgery of vestibular schwannomas. Int J Radiat Oncol Biol Phys 2002; 54:35–44.PubMedGoogle Scholar
  100. 100.
    Weber DC, Chan AW, Bussiere MR, et al. Proton beam radiosurgery for vestibular schwannoma: tumor control and cranial nerve toxicity. Neurosurgery 2003; 53:577–586.PubMedCrossRefGoogle Scholar
  101. 101.
    Fuss M, Hug EB, Schaefer RA, et al. Proton radiation therapy (PRT) for pediatric optic pathway gliomas: comparison with 3D planned conventional photons and a standard photon technique. Int J Radiat Oncol Biol Phys 1999; 45:1117–1126.PubMedCrossRefGoogle Scholar
  102. 102.
    Krengli M, Hug EB, Adams JA, et al. Proton radiation therapy for retinoblastoma: Comparison of various intraocular tumor locations and beam arrangements. Int J Radiat Oncol Biol Phys 2005; 61:583–593.PubMedGoogle Scholar
  103. 103.
    Lee CT, Bilton SD, Famiglietti RM, et al. Treatment planning with protons for pediatric retinoblastoma, and pelvic sarcoma: how do protons compare with other conformal techniques? Int J Radiat Oncol Biol Phys 2005; 63:362–372.PubMedCrossRefGoogle Scholar
  104. 104.
    Hug EB, Nevinny-Stickel M, Fuss M, et al. Conformal proton radiation treatment for retroperitoneal neuroblastoma: introduction of a novel technique. Med Pediatr Oncol 2001; 37:36–41.PubMedCrossRefGoogle Scholar
  105. 105.
    McAllister B, Archambeau JO, Nguyen MC, et al. Proton therapy for pediatric cranial tumors: preliminary report on treatment and disease-related morbidities. Int J Radiat Oncol Biol Phys 1997; 39:455–460.PubMedGoogle Scholar
  106. 106.
    Noel G, Habrand JL, Helfre S, et al. Proton beam therapy in the management of central nervous tumors in childhood: the preliminary experience of the Centre de Protonthérapie d’Orsay. Med Pediatr Oncol 2003; 40:309–315.PubMedCrossRefGoogle Scholar
  107. 107.
    Miralbell R, Lomax A, Bortfeld T, et al. Potential role of proton therapy in the treatment of pediatric medulloblastoma/primitive neuroectodermal tumors: reduction of the supratentorial target volume. Int J Radiat Oncol Biol Phys 1997; 38:477–484.PubMedCrossRefGoogle Scholar
  108. 108.
    ICRP. Recommendations of the International Commission on Radiobiological Protection. Publication 60. Annals of the ICRP. Oxford: Pergamon Press 1991; 21:1–3.Google Scholar
  109. 109.
    Miralbell R, Lomax A, Cella L, Schneider U. Potential reduction of the incidence of radiation-induced second cancers by using proton beams in the treatment of pediatric tumors. Int J Radiat Oncol Biol Phys 2002; 54:824–829.PubMedGoogle Scholar
  110. 110.
    Schoenthaler R, Fullerton B, Maas A, et al. Relationship between dose to auditory pathways and audiological outcomes in skull-base tumor patients receiving high-dose proton-photon radiotherapy. Int J Radiat Oncol Biol Phys 1996; 36:291.CrossRefGoogle Scholar
  111. 111.
    Cella L, Lomax A, Miralbell R. Potential role of intensity modulated proton beams in prostate cancer radiotherapy. Int J Radiat Oncol Biol Phys 2001; 49:217–223.PubMedGoogle Scholar
  112. 112.
    Slater JD, Rossi CJ Jr, Yonemoto LT, et al. Conformal proton therapy for early-stage prostate cancer. Urology 1999; 53:978–984.PubMedCrossRefGoogle Scholar
  113. 113.
    Shipley WU, Verhey LJ, Munzenrider JE, et al. Advanced prostate cancer: the results of a randomized comparative trial of high dose irradiation boosting with conformal protons compared with conventional dose irradiation using photons alone. Int J Radiat Oncol Biol Phys 1995; 32:3–12.PubMedGoogle Scholar
  114. 114.
    Benk VA, Adams JA, Shipley WU, et al. Late rectal bleeding following combined X-ray and proton high dose irradiation for patients with stages T3–T4 prostate carcinoma. Int J Radiat Oncol Biol Phys 1993; 26:551–557.PubMedGoogle Scholar
  115. 115.
    Cozzi L, Fogliata A, Lomax A, Bolsi A. A treatment planning comparison of 3D conformal therapy, intensity modulated photon therapy and proton therapy for treatment of advanced head and neck tumours. Radiother Oncol 2001; 61:287–297.PubMedCrossRefGoogle Scholar
  116. 116.
    Miralbell R, Cella L, Weber D, Lomax A. Optimizing radiotherapy of orbital and paraorbital tumors: intensity-modulated X-ray beams vs. intensity-modulated proton beams. Int J Radiat Oncol Biol Phys 2000; 47:1111–1119.PubMedGoogle Scholar
  117. 117.
    Santoni R, Liebsch N, Finkelstein DM, et al. Temporal lobe (TL) damage following surgery and high-dose photon and proton irradiation in 96 patients affected by chordomas and chondrosarcomas of the base of the skull. Int J Radiat Oncol Biol Phys 1998; 41:59–68.PubMedGoogle Scholar
  118. 118.
    Glosser G, McManus P, Munzenrider J, et al. Neuropsychological function in adults after high dose fractionated radiation therapy of skull base tumors. Int J Radiat Oncol Biol Phys 1997; 38:231–239.PubMedGoogle Scholar
  119. 119.
    Debus J, Hug EB, Liebsch NJ, et al. Brainstem tolerance to conformal radiotherapy of skull base tumors. Int J Radiat Oncol Biol Phys 1997; 39:967–975.PubMedGoogle Scholar
  120. 120.
    Marucci L, Niemierko A, Liebsch N, et al. Spinal cord tolerance to high dose fractionated 3D conformal proton-photon irradiation as evaluated by equivalent uniform dose and dose volume histogram analysis. Radiother Oncol 2002; 64(Suppl 1):S55.Google Scholar
  121. 121.
    Slater JD, Austin-Seymour M, Munzenrider J, et al. Endocrine function following high dose proton therapy for tumors of the upper clivus. Int J Radiat Oncol Biol Phys 1988; 15:607–611.PubMedGoogle Scholar
  122. 122.
    Habrand JL, Austin-Seymour M, Birnbaum S, et al. Neurovisual outcome following proton radiation therapy. Int J Radiat Oncol Biol Phys 1989; 16:1601–1606.PubMedGoogle Scholar
  123. 123.
    Kim J, Munzenrider JE, Maas A, et al. Optic neuropathy following combined proton and photon radiotherapy for base of skull tumors. Int J Radiat Oncol Biol Phys 1997; 39:272.Google Scholar
  124. 124.
    Urie MM, Fullerton B, Tatsuzaki H, et al. A dose response analysis of injury to cranial nerves and/or nuclei following proton beam radiation therapy. Int J Radiat Oncol Biol Phys 1992; 23:27–39.PubMedGoogle Scholar
  125. 125.
    Lundkvist J, Ekman M, Ericsson SR, et al. Cost-effectiveness of proton radiation in the treatment of childhood medulloblastoma. Cancer 2005; 103:793–801.PubMedCrossRefGoogle Scholar
  126. 126.
    Malka V, Fritzler S, Lefebvre E, et al. Practicability of protontherapy using compact laser systems. Med Phys 2004; 31:1587–1592.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Georges Noel
    • 1
  • Markus Fitzek
    • 2
  • Loïc Feuvret
    • 3
  • Jean Louis Habrand
    • 4
  1. 1.Department of RadiotherapyCentre de lutte contre le Paul StraussStrasbourgFrance
  2. 2.Radiation Oncology Center, Tufts-New England CenterTufts University School of MedicineBostonUSA
  3. 3.Centre de protonthérapie d’Orsay-Institut CurieCampus universitaireOrsayFrance
  4. 4.CPO-Institut CurieOrsayFrance

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