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Linear Accelerator Radiosurgery

  • William A. Friedman

Abstract

Stereotactic radiosurgery (SRS) is a minimally invasive treatment modality that delivers a large, single dose of radiation to a specific intracranial target while sparing surrounding tissue. Unlike conventional fractionated radiotherapy, SRS does not maximally exploit the higher radiosensitivity of brain lesions relative to normal brain (therapeutic ratio). Its selective destruction is dependent mainly on sharply focused, high-dose radiation and a steep dose gradient away from the defined target. The biological effect is irreparable cellular damage (probably via DNA strand breaks) and delayed vascular occlusion within the high-dose target volume. Because a therapeutic ratio is not required, traditionally radioresistant lesions can be treated. Because destructive doses are used, however, any normal structure included in the target volume is subject to damage.

Keywords

Brain Metastasis Malignant Glioma Radiat Oncol Biol Phys Gamma Knife Radiation Therapy Oncology Group 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • William A. Friedman
    • 1
  1. 1.Department of NeurosurgeryUniversity of Florida College of MedicineGainesvilleUSA

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