Abstract
This chapter presents a discussion of the means, primarily electrical, by which the parts of an organism communicate with each other. We will see that this communication is not like that of a conducting wire; rather, it involves a self-propagating change in the ionic conductance of the cell membrane. The nerve cell, or neuron, has an energy-requiring, steady-state condition in which the interior of the cell is at a negative potential relative to the exterior. Information transfer takes the form of a disruption of this steady-state condition, in which the polarity of a local region of the membrane is transiently reversed. This reversal is self-propagating, and is called an action potential. It is an all-or-none phenomenon: Either it occurs in full form or it doesn’t occur at all. Neurons are separated by a synaptic cleft, and interneuronal transmission of information is chemically mediated. An action potential in a presynaptic neuron triggers the release of a neurotransmitter chemical that diffuses to the postsynaptic cell. The sum of all the excitatory and inhibitory neurotransmitters that reach a postsynaptic cell in a short period of time determines whether a new action potential is generated.
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References and Suggested Further Reading
Neuronal biology and physiology: E. N. Marieb, Human Anatomy and Physiology, Benjamin/Cummings Publishing, Redwood City, CA, 1992.
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Shonkwiler, R.W., Herod, J. (2009). Neurophysiology. In: Mathematical Biology. Undergraduate Texts in Mathematics. Springer, New York, NY. https://doi.org/10.1007/978-0-387-70984-0_7
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DOI: https://doi.org/10.1007/978-0-387-70984-0_7
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