Semaphorin Signaling During Cardiac Development

  • Toshihiko Toyofuku
  • Hitoshi Kikutani
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 600)


A number of semaphorins have been shown to play crucial roles as axon guidance cues in the wiring of the nervous system, including axon fasciculation, branching, and target selection. However, increasing evidence has also attested to the significance of semaphorins in the development of other organ systems, including the cardiovascular system. Targeted disruption of certain semaphorins or their receptors, has been shown to result in various defects in the vascular system. Furthermore, several studies have suggested that some semaphorins may contribute to the development of the cardiovascular system by controlling the migration of endothelial cells, cardiac myocytes, or their precursors. In this review, we will discuss how semaphorin signals are involved in regulation of cardiac cells and cardiac morphogenesis.


Planar Cell Polarity Endocardial Cushion Intracellular Signaling Mechanism Cardiac Neural Crest Cardiac Morphogenesis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Landes Bioscience and Springer Science+Business Media 2007

Authors and Affiliations

  • Toshihiko Toyofuku
  • Hitoshi Kikutani
    • 1
    • 2
  1. 1.Department of Molecular Immunology, Research Institute for Microbial DiseasesOsaka UniversityOsakaJapan
  2. 2.CRESTJapan Science and Technology CorporationJapan

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