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Modulation of Semaphorin Signaling by Ig Superfamily Cell Adhesion Molecules

  • Ahmad Bechara
  • Julien Falk
  • Frédéric Moret
  • Valérie Castellani
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 600)

Abstract

During axon navigation, growth cones continuously interact with molecular cues in their environment, some of which control adherence and bundle assembly, others axon elongation and direction. Growth cone responses to these different environmental cues are tightly coordinated during the development of neuronal projections. Several recent studies show that axon sensitivity to guidance cues is modulated by extracellular and intracellular signals. This regulation may enable different classes of cues to combine their effects and may also represent important means for diversifying pathway choices and for compensating for the limited number of guidance cues. This chapter focuses on the modulation exerted by Ig Superfamily cell adhesion molecules (IgSFCAMs) on guidance cues of the class III secreted semaphorins

Keywords

Growth Cone Transfected COS7 Cell Commissural Axon Growth Cone Collapse Dorsal Root Entry Zone 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Landes Bioscience and Springer Science+Business Media 2007

Authors and Affiliations

  • Ahmad Bechara
  • Julien Falk
  • Frédéric Moret
  • Valérie Castellani
    • 1
  1. 1.Centre de Génétique Moléculaire et Cellulaire (CGMC) UMR CNRS 5534Université Claude Bernard, Lyon1Villeurbanne cedexFrance

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