Intracellular Kinases in Semaphorin Signaling

  • Aminul Ahmed
  • Britta J. Eickholt
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 600)


Originally identified as collapse-inducing and repellent proteins for neuronal processes, semaphorins are now implicated in a diverse array of cellular responses, contributing not only to embryonic development, but also to the maintenance of tissue integrity in the adult organism. In addition, semaphorins play a role in the pathological context. Some Semaphorins can act at a distance, facilitating the navigation of cells or axonal process, whilst others evoke responses in a contact-dependent fashion. The intracellular signaling mechanisms employed by the semaphorins are beginning to be determined, and much work in recent years implicates a host of intracellular kinases in mediating Semaphorin function. These include the tyrosine kinase Fyn and the serine/threonine kinases Cdk5, GSK3, MAPK, and LIMK, and the lipid kinase PI3K. What follows is a review of this work with respect to their functions in mediating specific semaphorin-induced responses


Growth Cone Intracellular Kinase Growth Cone Collapse Neuronal Growth Cone Intracellular Signaling Mechanism 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Landes Bioscience and Springer Science+Business Media 2007

Authors and Affiliations

  • Aminul Ahmed
  • Britta J. Eickholt
    • 1
  1. 1.MRC Centre for Developmental NeurobiologyKing’s College LondonLondonUK

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