Microbial Physiology

  • Paul S. Hoffman
Part of the Infectious Diseases And Pathogenesis book series (IAPA)


Krebs Cycle Major Outer Membrane Protein Intracellular Growth Integration Host Factor Microbial Physiology 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Amano K, Williams JC 1983. Partial characterization of peptidoglycan-associated proteins of Legionella pneumophila. J. Biochem (Tokyo). 94:601–606.Google Scholar
  2. Aragon V, Kurtz S, Cianciotto NP (2001). Legionella pneumophila major acid phosphatase and its role in intracellular infection. Infect. Immun. 69:177–185.PubMedCrossRefGoogle Scholar
  3. Baker LM, Raudonikinene A, Hoffman PS, and Poole LB (2001) An essential thioredoxindependent peroxiredoxin from Helicobacter pylori: genetic and kinetic characterization. J. Bacteriol. 183:1961–1973.PubMedCrossRefGoogle Scholar
  4. Bandyopadhyay P, Steinman HM (2000) Catalase-peroxidases of Legionella pneumophila: cloning of the katA gene and studies of KatA function. J. Bacteriol. 182:6679–6686.PubMedCrossRefGoogle Scholar
  5. Bellinger-Kawahara C, Horwitz MA (1990). Complement component C3 fixes selectively to the major outer membrane protein (MOMP) of Legionella pneumophila and mediates phagocytosis of liposome-MOMP complexes by human monocytes. J. Exp. Med. 172: 1201–1210.PubMedCrossRefGoogle Scholar
  6. Braedel-Ruoff S, Faigle M, Hilf N, Neumeister B, Schild H (2005) Legionella pneumophila mediated activation of dendritic cells involves CD14 and TLR2. J Endotoxin Res. 11:89–96.PubMedGoogle Scholar
  7. Bryk R, Lima CD, Erdjument-Bromage H, Tempst P, Nathan C (2002) Metabolic enzymes of mycobacteria linked to antioxidant defense by a thioredoxin-like protein. Science. 295:1073–1077.PubMedCrossRefGoogle Scholar
  8. Butler CA, Hoffman PS (1990) Characterization of a major 31 kilodalton peptidoglycan-bound protein of Legionella pneumophila. J. Bacteriol. 172:2401–2407.PubMedGoogle Scholar
  9. Butler CA, Street ED, Hatch TP, Hoffman PS (1985) Disulfide-bonded outer membrane proteins in the genus Legionella. Infect. Immun. 48:14–18.PubMedGoogle Scholar
  10. Byrd TF, Horwitz MA (1989) Interferon gamma-activated human monocytes downregulate transferrin receptors and inhibit the intracellular multiplication of Legionella pneumophila by limiting the availability of iron. J. Clin Invest. 83:1457–1465.PubMedCrossRefGoogle Scholar
  11. Cazalet C, Rusniok C, Bruggemann H, Zidane N, Magnier A, Ma L, Tichit M, Jarraud S, Bouchier C, Vandenesch F, Kunst F, Etienne J, Glaser P, Buchrieser C (2004) Evidence in the Legionella pneumophila genome for exploitation of host cell functions and high genome plasticity. Nat Genet. 36:1165–1173.PubMedCrossRefGoogle Scholar
  12. Chalker AF, Minehart HW, Hughes NJ, Koretke KK, Brown JR, Lonetto MA, Warren PV, Stanhope MJ, Lupas A, Hoffman PS (2001) Systematic identification of unique essential genes in Helicobacter pylori by genome prioritization and allelic replacement mutagenesis J. Bacteriol 183:1259–1268.PubMedCrossRefGoogle Scholar
  13. Chien M, Morozova I, Shi S, Sheng H, Chen J, Gomez SM, Asamani G, Hill GK, Nuara J, Feder M, Rineer J, Greenberg JJ, Steshenko V, Park SH, Zhao B, Teplitskaya E, Edwards JR, Pampou S, Georghiou A, I. C. Chou IC, Iannuccilli W, Ulz ME, Kim DH, Geringer-Sameth A, Goldsberry C, Morozov P, Fischer SG, Segal G, Qu X, Rzhetsky A, Zhang P, Cayanis E, De Jong PJ, Ju J, Kalachikov S, Shuman HA, Russo JJ (2004) The genomic sequence of the accidental pathogen Legionella pneumophila. Science. 305:1966–1968.PubMedCrossRefGoogle Scholar
  14. Dietrich C, Heuner K, Brand B, Hacker J, and Steinert M (2001) The flagellum of Legionella pneumophila positively affects the early phase of infection of eukaryotic host cells. Infect. Immun. 69:2116–2122.PubMedCrossRefGoogle Scholar
  15. Engleberg NC, Carter C, Weber DR, Cianciotto NP, Eisenstein BI (1989) DNA sequence of mip, a Legionella pneumophila gene associated with macrophage infectivity. Infect Immun. 57:1263–1270.PubMedGoogle Scholar
  16. Faulkner G, Garduño RA (2002) Ultrastructural analysis of differentiation in Legionella pneumophila. J Bacteriol 184: 7025–7041.PubMedCrossRefGoogle Scholar
  17. Feeley JC, Gibson RJ, Gorman GW, Langford NC, Rasheed JK, Mackel DC, Baine WB (1979). Charcoal-yeast extract agar: primary isolation medium for Legionella pneumophila. J. Clin Microbiol. 10:437–441.PubMedGoogle Scholar
  18. Fields BS (1996) Molecular ecology of legionellae. Trends in Microbiol. 4:286–290.CrossRefGoogle Scholar
  19. Fischer G, Bang H, Ludwig B, Mann K, Hacker J (1992) Mip protein of Legionella pneumophila exhibits peptidyl-prolyl-cis/trans isomerase (PPlase) activity. Mol Microbiol. 6:1375–1383.PubMedCrossRefGoogle Scholar
  20. Flieger A, Gong S, Faigle M, Stevanovic S, Cianciotto NP, and Neumeister B (2001) Novel lysophospholipase A secreted by Legionella pneumophila. J. Bacteriol. 183:2121–2124.PubMedCrossRefGoogle Scholar
  21. Gabay JE, Blake M, Niles WD, Horwitz MA (1985) Purification of Legionella pneumophila major outer membrane protein and demonstration that it is a porin. J. Bacteriol. 162:85–91.PubMedGoogle Scholar
  22. Garduño RA, Garduño E, Hoffman PS (1998a) Role of the Hsp60 chaperonin of Legionella pneumophila in mediating invasion in a HeLa cell model. Infect. Immun. 66:4602–4610.Google Scholar
  23. Garduño R, Quinn FD, Hoffman PS (1998b) HeLa cells as a model to study the invasiveness and biology of Legionella pneumophila. Can. J. Microbiology. 44:430–440.CrossRefGoogle Scholar
  24. Garduño, RA, Garduño E, Hiltz M, and Hoffman PS (2002) Intracellular growth of Legionella pneumophila gives rise to differentiated form dissimilar to stationary phase forms. Infect. Immun. 70: 6273–6283.PubMedCrossRefGoogle Scholar
  25. Greub G, Raoult D (2003) Morphology of Legionella pneumophila according to their location within Hartmanella vermiformis. Res Microbiol 154: 619–621.PubMedCrossRefGoogle Scholar
  26. Hiltz MF, Sisson GR, Brassinga AKC, Garduño E, Garduño RA, Hoffman PS (2004) Expression of magA in Legionella pneumophila Philadelphia-1 is developmentally regulated and a marker of MIF formation. J. Bacteriol. 186:3038–3045.PubMedCrossRefGoogle Scholar
  27. Hoffman, PS (1984) Bacterial Physiology. In C. Thornsberry et al. (eds.). Legionella, Proceedings of the 2nd International Symposium, ASM, Washington, DC, pp. 61–67.Google Scholar
  28. Hoffman PS (2001) Bacterial Physiology of Helicobacter pylori. In H. Friedman, P.S. Hoffman and Y. Yamamoto (eds.). Immunology and Pathogenesis of Helicobacter pylori. Kluwer Press, USA.Google Scholar
  29. Hoffman PS, and Pine L (1982) Respiratory physiology and cytochrome content of Legionella pneumophila. Curr. Microbiol. 7:351–356.CrossRefGoogle Scholar
  30. Hoffman PS, Pine L, and Bell S (1983) Production of superoxide and hydrogen peroxide in medium used for culture of Legionella pneumophila: catalytic decomposition by charcoal. Appl. Environ. Microbiol. 45:784–791.PubMedGoogle Scholar
  31. Hoffman PS, Houston L, Butler CA (1990) Legionella pneumophila htpAB heat shock operon: nucleotide sequence and expression of the 60-kilodalton antigen in L. pneumophila-infected HeLa cells. Infect. Immun. 58:3380–3387.PubMedGoogle Scholar
  32. Hoffman PS, Seyer JH, and Butler CA (1992) Molecular characterization of the 28 and 31 kilodalton subunits of the Legionella pneumophila porin. J. Bacteriol. 174:908–913.PubMedGoogle Scholar
  33. Keen MG, Hoffman PS (1984) Metabolic pathways and nitrogen metabolism in Legionella pneumophila. Curr. Microbiol. 11:81–88.CrossRefGoogle Scholar
  34. Keen MG, Hoffman PS (1989) Characterization of a protease mutant of Legionella pneumophila and demonstration that the protease is responsible for the hemolytic and cytotoxic phenotyes. Infect. & Immun. 57:732–738.Google Scholar
  35. Luck PC, Freier T, Steudel C, Knirel YA, Luneberg E, Zahringer U, Helbig JHA (2001) Point mutation in the active site of Legionella pneumophila O-acetyltransferase results in modified lipopolysaccharide but does not influence virulence. Int J Med Microbiol 291:345–352.PubMedCrossRefGoogle Scholar
  36. Moffat JF, Edelstein PH, Regula DP Jr, Cirillo JD, Tompkins LS (1994) Effects of an isogenic Zn-metalloprotease-deficient mutant of Legionella pneumophila in a guinea-pig pneumonia model. Mol. Microbiol. 12:693–705.PubMedCrossRefGoogle Scholar
  37. Molofsky AB, Swanson MS (2004) Differentiate to thrive: lessons from the Legionella pneumophila life cycle. Mol. Microbiol. 53:29–40.PubMedCrossRefGoogle Scholar
  38. Naylor J, Cianciotto NP (2004) Cytochrome c maturation proteins are critical for in vivo growth of Legionella pneumophila. FEMS Microbiol Lett. 241:249–256.PubMedCrossRefGoogle Scholar
  39. Neumeister B, Faigle BM, Sommer M, Zähringer U, Stelter F, Menzel R, Schütt C, Northoff H (1998) Low endotoxic potential of Legionella pneumophila lipopolysaccharide due to failure of interaction with the monocyte lipopolysaccharide receptor CD14. Infect. Immun. 66:4151–4157.PubMedGoogle Scholar
  40. Pine L, Hoffman PS, Malcolm GB, Benson RF, Keen MG (1984) Determination of catalase, peroxidase, and superoxide dismutase within the genus Legionella. J. Clin. Microbiol. 20:421–429.PubMedGoogle Scholar
  41. Pine L, Hoffman PS, Malcolm GB, Benson RF, Franzus MJ (1986) Role of keto acids and reduced-oxygen-scavenging enzymes in the growth of Legionella species. J. Clin. Microbiol. 23:33–42.PubMedGoogle Scholar
  42. Rankin S, Li Z, Isberg RR (2002) Macrophage-induced genes of Legionella pneumophila: protection from reactive intermediates and solute imbalance during intracellular growth. Infect. Immun. 70:3637–3648.PubMedCrossRefGoogle Scholar
  43. Retzlaff C, Yamamoto Y, Okubo S, Hoffman PS, Friedman H, Klein TW (1996) Legionella pneumophila-heat shock protein induced increase of interleukin-1? mRNA innvolves protein kinase C signalling in macrophages. Immunol. 89:281–288.CrossRefGoogle Scholar
  44. Ristroph JD, Hedlund KW, Gowda S (1981) Chemically defined medium for Legionella pneumophila growth. J. Clin Microbiol. 13:115–119.PubMedGoogle Scholar
  45. Rossier O, Cianciotto NP (2005) The Legionella pneumophila tatB gene facilitates secretion of phospholipase C, growth under iron-limiting conditions, and intracellular infection. Infect. Immun. 73:2020–2032.PubMedCrossRefGoogle Scholar
  46. Sauer JD, Bachman MA, Swanson MS (2005) The phagosomal transporter A couples threonine acquisition to differentiation and replication of Legionella pneumophila in macrophages. PNAS 102:9924–9929.PubMedCrossRefGoogle Scholar
  47. Stone BJ, Abu Kwaik Y (1998) Expression of multiple pili by Legionella pneumophila: identification and characterization of a type IV pilin gene its role in adherence to mammalian and protozoan cells. Infect. Immun. 66:1768–1775.PubMedGoogle Scholar
  48. St. John G, Steinman HM (1996) Periplasmic copper-zinc superoxide dismutase of Legionella pneumophila: role in stationary-phase survival. J. Bacteriol. 178:1578–1584.Google Scholar
  49. Thorpe TC, Miller RD (1981) Extracellular enzymes of Legionella pneumophila. Infect. Immun. 33:632–6335.PubMedGoogle Scholar
  50. Warren WJ, Miller RD (1979) Growth of Legionnaires disease bacterium (Legionella pneumophila) in chemically defined medium. J. Clin Microbiol. 10:50–55.PubMedGoogle Scholar
  51. Weeratna R, Stamler DA, Edelstein PH, Ripley M, Marrie TJ, Hoskin D, Hoffman PS (1994) Human and guinea pig immune responses to Legionella pneumophila protein antigens: Vaccination of guinea pigs with OmpS, but not Hsp60 induces cell-mediated and protective immunity. Infect. Immun. 62:3454–3462.PubMedGoogle Scholar
  52. Weissgerber P, Faigle M, Northoff H, Neumeister B. (2003) Investigation of mechanisms involved in phagocytosis of Legionella pneumophila by human cells. FEMS Microbiol Lett. 219:173–179.PubMedCrossRefGoogle Scholar
  53. Wieland H, Ullrich S, Lang F, Neumeister B (2005) Intracellular multiplication of Legionella pneumophila depends on host cell amino acid transporter SLC1A5. Mol Microbiol. 55:1528–1537.PubMedCrossRefGoogle Scholar
  54. Zou CH, Knirel YA, Helbig JH, Zähringer U, Mintz CS (1999) Molecular cloning and characterization Legionella pneumophila serogroup lipopolysaccharide. J. Bacteriol. 181:4137–4141.PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Paul S. Hoffman

There are no affiliations available

Personalised recommendations