Nonspecific Stimulation of Immunity Against Legionella

  • James Rogers
  • Amal Hakki
  • Herman Friedman
Part of the Infectious Diseases And Pathogenesis book series (IAPA)


Chlamydia Trachomatis Epigallocatechin Gallate EGCG Treatment Nonspecific Stimulation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Ahn, J. Y., Song, J. Y., Yun, Y. S., Jeong, G., and Choi, I. S. 2006. Protection of Staphylococcus aureus-infected septic mice by suppression of early acute inflammation and enhanced antimicrobial activity by ginsan. FEMS Immunol Med Microbiol 46, 187–197.PubMedCrossRefGoogle Scholar
  2. Akamine, M., Higa, F., Arakaki, N., Kawakami, K., Takeda, K., Akira, S., and Saito, A. 2005. Differential roles of Toll-like receptors 2 and 4 in in vitro responses of macrophages to Legionella pneumophila. Infect Immun 73, 352–361.PubMedCrossRefGoogle Scholar
  3. Alibek, K. 1999. The Soviet Union’s anti-agricultural biological weapons. Ann N Y Acad Sci 894, 18–19.PubMedCrossRefGoogle Scholar
  4. Archer, K. A., and Roy, C. R. 2006. MyD88-dependent responses involving toll-like receptor 2 are important for protection and clearance of Legionella pneumophilain a mouse model of Legionnaires’ disease. Infect Immun 74, 3325–3333.PubMedCrossRefGoogle Scholar
  5. Banskota, A. H., Tezuka, Y., and Kadota, S. 2001. Recent progress in pharmacological research of propolis. Phytother Res 15, 561–571.PubMedCrossRefGoogle Scholar
  6. Haycock, J. W. 1993. Multiple signaling pathways in bovine chromaffin cells regulate tyrosine hydroxylase phosphorylation at Ser19, Ser31, and Ser40. Neurochem Res 18, 15–26.PubMedCrossRefGoogle Scholar
  7. Heath, W. R., Belz, G. T., Behrens, G. M., Smith, C. M., Forehan, S. P., Parish, I. A., Davey, G. M., Wilson, N. S., Carbone, F. R., and Villadangos, J. A. 2004. Cross-presentation, dendritic cell subsets, and the generation of immunity to cellular antigens. Immunol Rev 199, 9–26.PubMedCrossRefGoogle Scholar
  8. Khalil, M. L. 2006. Biological activity of bee propolis in health and disease. Asian Pac J Cancer Prev 7, 22–31.PubMedGoogle Scholar
  9. Mabe, K., Yamada, M., Oguni, I., and Takahashi, T. 1999. In vitro and in vivo activities of tea catechins against Helicobacter pylori. Antimicrob Agents Chemother 43, 1788–1791.PubMedGoogle Scholar
  10. Masihi, K. N. 2000. Immunomodulatory agents for prophylaxis and therapy of infections. Int J Antimicrob Agents 14, 181–191.PubMedCrossRefGoogle Scholar
  11. Matsunaga, K., Klein, T. W., Friedman, H., and Yamamoto, Y. 2001a. Legionella pneumophilareplication in macrophages inhibited by selective immunomodulatory effects on cytokine formation by epigallocatechin gallate, a major form of tea catechins. Infect Immun 69, 3947–3953.CrossRefGoogle Scholar
  12. Matsunaga, K., Klein, T. W., Newton, C., Friedman, H., and Yamamoto, Y. 2001b. Legionella pneumophilasuppresses Interleukin-12 production by macrophages. Infect Immun 69, 1929–1933.CrossRefGoogle Scholar
  13. Matsunaga, K., Klein, T. W., Friedman, H., and Yamamoto, Y. 2002. Epigallocatechin gallate, a potential immunomodulatory agent of tea components, diminishes cigarette smoke condensate-induced suppression of anti-Legionella pneumophilaactivity and cytokine responses of alveolar macrophages. Clin Diagn Lab Immunol 9, 864–871.PubMedCrossRefGoogle Scholar
  14. McColl, S. R. 2002. Chemokines and dendritic cells: a crucial alliance. Immunol Cell Biol 80, 489–496.PubMedCrossRefGoogle Scholar
  15. Morre, D. J., Morre, D. M., Sun, H., Cooper, R., Chang, J., and Janle, E. M. 2003. Tea catechin synergies in inhibition of cancer cell proliferation and of a cancer specific cell surface oxidase (ECTO-NOX). Pharmacol Toxicol 92, 234–241.PubMedCrossRefGoogle Scholar
  16. Musikacharoen, T., Matsuguchi, T., Kikuchi, T., and Yoshikai, Y. 2001. NF-kappa B and STAT5 play important roles in the regulation of mouse Toll-like receptor 2 gene expression. J Immunol 166, 4516–4524.PubMedGoogle Scholar
  17. Neild, A. L., and Roy, C. R. 2003. Legionella reveal dendritic cell functions that facilitate selection of antigens for MHC class II presentation. Immunity 18, 813–823.PubMedCrossRefGoogle Scholar
  18. Plitz, T., Huffstadt, U., Endres, R., Schaller, E., Mak, T. W., Wagner, H., and Pfeffer, K. 1999. The resistance against Listeria monocytogenes and the formation of germinal centers depend on a functional death domain of the 55 kDa tumor necrosis factor receptor. Eur J Immunol 29, 581–591.PubMedCrossRefGoogle Scholar
  19. Rescigno, M., Martino, M., Sutherland, C. L., Gold, M. R., and Ricciardi-Castagnoli, P. 1998. Dendritic cell survival and maturation are regulated by different signaling pathways. J Exp Med 188, 2175–2180.PubMedCrossRefGoogle Scholar
  20. Sallusto, F., Mackay, C. R., and Lanzavecchia, A. 2000. The role of chemokine receptors in primary, effector, and memory immune responses. Annu Rev Immunol 18, 593–620.PubMedCrossRefGoogle Scholar
  21. Salman, H., Bergman, M., Bessler, H., Punsky, I., and Djaldetti, M. 1999. Effect of a garlic derivative (alliin) on peripheral blood cell immune responses. Int J Immunopharmacol 21, 589–597.PubMedCrossRefGoogle Scholar
  22. Sporri, R., Joller, N., Albers, U., Hilbi, H., and Oxenius, A. 2006. MyD88-dependent IFN-gamma production by NK cells is key for control of Legionella pneumophilainfection. J Immunol 176, 6162–6171.PubMedGoogle Scholar
  23. Suganuma, M., Okabe, S., Sueoka, N., Sueoka, E., Matsuyama, S., Imai, K., Nakachi, K., and Fujiki, H. 1999. Green tea and cancer chemoprevention. Mutat Res 428, 339–344.PubMedGoogle Scholar
  24. Yamaguchi, K., Honda, M., Ikigai, H., Hara, Y., and Shimamura, T. 2002. Inhibitory effects of (–)-epigallocatechin gallate on the life cycle of human immunodeficiency virus type 1 (HIV-1). Antiviral Res 53, 19–34.PubMedCrossRefGoogle Scholar
  25. Yamazaki, T., Inoue, M., Sasaki, N., Hagiwara, T., Kishimoto, T., Shiga, S., Ogawa, M., Hara, Y., and Matsumoto, T. 2003. In vitro inhibitory effects of tea polyphenols on the proliferation of Chlamydia trachomatis and Chlamydia pneumoniae. Jpn J Infect Dis 56, 143–145.PubMedGoogle Scholar
  26. Yanagawa, Y., Yamamoto, Y., Hara, Y., and Shimamura, T. 2003. A combination effect of epigallocatechin gallate, a major compound of green tea catechins, with antibiotics on Helicobacter pylori growth in vitro. Curr Microbiol 47, 244–249.PubMedCrossRefGoogle Scholar
  27. Yang, C. S., Maliakal, P., and Meng, X. 2002. Inhibition of carcinogenesis by tea. Annu Rev Pharmacol Toxicol 42, 25–54.PubMedCrossRefGoogle Scholar
  28. Yu, R., Park, J. W., Kurata, T., and Erickson, K. L. 1998. Modulation of select immune responses by dietary capsaicin. Int J Vitam Nutr Res 68, 114–119.PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • James Rogers
  • Amal Hakki
  • Herman Friedman

There are no affiliations available

Personalised recommendations