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Legionella pneumophila Pathogenesis: Lessons Learned from Genomics

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Legionella pneumophila

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References

  • Aldridge P, Paul R, Goymer P, Rainey P, Jenal U (2003) Role of the GGDEF regulator PleD in polar development of Caulobacter crescentus. Mol Microbiol 47:1695–708.

    Article  PubMed  CAS  Google Scholar 

  • Amer AO, Swanson MS (2005) Autophagy is an immediate macrophage response to Legionella pneumophila. Cell Microbiol 7:765–778.

    Article  PubMed  CAS  Google Scholar 

  • Baar C, Eppinger M, Raddatz G, Simon J, Lanz C, Klimmek O, Nandakumar R, Gross R, Rosinus A, Keller H, Jagtap P, Linke B, Meyer F, Lederer H, Schuster SC (2003) Complete genome sequence and analysis of Wolinella succinogenes. Proc Natl Acad Sci USA 100:11690–11695.

    Article  PubMed  CAS  Google Scholar 

  • Baptestea E, Moreirab D, Philippe H (2003) Rampant horizontal gene transfer and phos pho-donor change in the evolution of the phosphofructokinase. Gene 318:185–191.

    Article  CAS  Google Scholar 

  • Barz C, Abahji TN, Trulzsch K, Heesemann J (2000) The Yersinia Ser/Thr protein kinase YpkA/YopO directly interacts with the small GTPases RhoA and Rac-1. FEBS Lett 482:139–143.

    Article  PubMed  CAS  Google Scholar 

  • Batrukova MA, Betin VL, Rubtsov AM, Lopina OD (2000) Ankyrin: structure, properties, and functions. Biochemistry (Mosc) 65:395–408.

    CAS  Google Scholar 

  • Benz I, Schmidt MA (1992) AIDA-I, the adhesin involved in diffuse adherence of the diarrhoeagenic Escherichia coli strain 2787 (O126:H27), is synthesized via a precursor molecule. Mol Microbiol 6:1539–1546.

    Article  PubMed  CAS  Google Scholar 

  • Berger KH, Isberg RR (1993) Two distinct defects in intracellular growth complemented by a single genetic locus in Legionella pneumophila. Mol Microbiol 7:7–19.

    Article  PubMed  CAS  Google Scholar 

  • Bezanson G, Fernandez R, Haldane D, Burbridge S, Marrie T (1994) Virulence of patient and water isolates of Legionella pneumophila in guinea pigs and mouse L929 cells varies with bacterial genotype. Can J Microbiol 40:426–431.

    Article  PubMed  CAS  Google Scholar 

  • Biederbick A, Rose S, Elsasser HP (1999) A human intracellular apyrase-like protein, LALP70, localizes to lysosomal/autophagic vacuoles. J Cell Sci 112:2473–2484.

    PubMed  CAS  Google Scholar 

  • Brassinga AK, Hiltz MF, Sisson GR, Morash MG, Hill N, Garduño E, Edelstein PH, Garduño RA, Hoffman PS (2003) A 65-Kilobase Pathogenicity Island Is Unique to Philadelphia-1 Strains of Legionella pneumophila. J Bacteriol 185:4630–3637.

    Article  PubMed  CAS  Google Scholar 

  • Brown A, Vickers RM, Elder EM, Lema M, Garrity GM (1982) Plasmid and surface antigen markers of endemic and epidemic Legionella pneumophila strains. J Clin Microbiol 16:230–235.

    PubMed  CAS  Google Scholar 

  • Brüggemann H, Hagman A, Jules M, Sismeiro O, Dillies M, Gouyette C, Kunst F, Steinert M, Heuner K, Coppée J, Buchrieser C (2006) Virulence strategies for infecting phagocytes deduced from the in vivo transcriptional program of Legionella pneumophila. Cell Microbiol 8(8):1228–1240.

    Article  PubMed  CAS  Google Scholar 

  • Carsiotis M, Stocker BA, Weinstein DL, O’Brien AD (1989) A Salmonella typhimurium virulence gene linked to flg. Infect Immun. 57:3276–3280.

    PubMed  CAS  Google Scholar 

  • Cazalet C, Rusniok C, Bruggemann H, Zidane N, Magnier A, Ma L, Tichit M, Jarraud S, Bouchier C, Vandenesch F, Kunst F, Etienne J, Glaser P, Buchrieser C (2004) Evidence in the Legionella pneumophila genome for exploitation of host cell functions and high genome plasticity. Nat Genet 36:1165–1173.

    Article  PubMed  CAS  Google Scholar 

  • Cazalet C, Jarraud S, Ghavi-Helm Y, Allignet J, Kunst F, Etienne J, Glaser P, Buchrieser C (2005a) Genetic diversity of the species Legionella pneumophila. In: Cianciotto NP (ed.) Legionella 2005. ASM Press, Chicago, USA.

    Google Scholar 

  • Cazalet C, Rusniok C, Bruggemann H, Jarraud S, Bouchier C, Vandenesch F, Kunst F, Etienne J, Glaser P, Buchrieser C (2005b) Comparative Genomics of the Causative Agent of Legionnaires’ Disease, Legionella pneumophila and Related Species XI International Congress of Bacteriology and Applied Microbiology (IUMS), San Francisco, 23–28 July.

    Google Scholar 

  • Chen J, de Felipe KS, Clarke M, Lu H, Anderson OR, Segal G, Shuman HA (2004) Legionella effectors that promote nonlytic release from protozoa. Science 303:1358–1361.

    Article  PubMed  CAS  Google Scholar 

  • Chien M, Morozova I, Shi S, Sheng H, Chen J, Gomez SM, Asamani G, Hill K, Nuara J, Feder M, Rineer J, Greenberg JJ, Steshenko V, Park SH, Zhao B, Teplitskaya E, Edwards JR, Pampou S, Georghiou A, Chou IC, Iannuccilli W, Ulz ME, Kim DH, Geringer-Sameth A, Goldsberry C, Morozov P, Fischer SG, Segal G, Qu X, Rzhetsky A, Zhang P, Cayanis E, De Jong PJ, Ju J, Kalachikov S, Shuman HA, Russo JJ (2004) The genomic sequence of the accidental pathogen Legionella pneumophila. Science 305:1966–1968.

    Article  PubMed  CAS  Google Scholar 

  • Cole ST, Brosch R, Parkhill J, Garnier T, Churcher C, Harris D, Gordon SV, Eiglmeier K, Gas S, Barry CE, 3rd, Tekaia F, Badcock K, Basham D, Brown D, Chillingworth T, Connor R, Davies R, Devlin K, Feltwell T, Gentles S, Hamlin N, Holroyd S, Hornsby T, Jagels K, Barrell BG, et al. (1998) Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Nature 393:537–544.

    Article  PubMed  CAS  Google Scholar 

  • Conover GM, Derre I, Vogel JP, Isberg RR (2003) The Legionella pneumophila LidA protein: a translocated substrate of the Dot/Icm system associated with maintenance of bacterial integrity. Mol Microbiol 48:305–321.

    Article  PubMed  CAS  Google Scholar 

  • Derre I, Isberg RR (2005) LidA, a translocated substrate of the Legionella pneumophila type IV secretion system, interferes with the early secretory pathway. Infect Immun 73:4370–4380.

    Article  PubMed  CAS  Google Scholar 

  • Desvaux M, Parham NJ, Henderson IR (2004) The autotransporter secretion system. Res Microbiol 155:53–60

    Article  PubMed  CAS  Google Scholar 

  • Dhandayuthapani S, Blaylock MW, Bebear CM, Rasmussen WG, Baseman JB (2001) Peptide methionine sulfoxide reductase (MsrA) is a virulence determinant in Mycoplasma genitalium. J Bacteriol 183:5645–5650.

    Article  PubMed  CAS  Google Scholar 

  • Doyle RM, Heuzenroeder MW (2002) A mutation in an ompR-like gene on a Legionella longbeachae serogroup 1 plasmid attenuates virulence. Int J Med Microbiol 292:227–239.

    Article  PubMed  CAS  Google Scholar 

  • Farris M, Grant A, Richardson TB, O’Connor CD (1998) BipA: a tyrosine-phosphorylated GTPase that mediates interactions between enteropathogenic Escherichia coli (EPEC) and epithelial cells. Mol Microbiol 28:265–279.

    Article  PubMed  CAS  Google Scholar 

  • Feldman M, Segal G (2004) A specific genomic location within the icm/dot pathogenesis region of different Legionella species encodes functionally similar but nonhomologous virulence proteins. Infect Immun 72:4503–4511.

    Article  PubMed  CAS  Google Scholar 

  • Franceschini N, Boschi L, Pollini S, Herman R, Perilli M, Galleni M, Frere JM, Amicosante G, Rossolini GM (2001) Characterization of OXA-29 from Legionella (Fluoribacter) gormanii: molecular class D beta-lactamase with unusual properties. Antimicrob Agents Chemother 45:3509–3516.

    Article  PubMed  CAS  Google Scholar 

  • Glaser P, Frangeul L, Bluchrieser C, Rusniok C, Amend A, Baquero F, Berche P, Bloecker H, Brandt P, Chakraborty T, Charbit A, Chetouani F, Couve E, de Daruvar A, Dehoux P, Domann E, Dominguez-Bernal G, Duchaud E, Durant, Dussurget O, Entian KD, Fsihi H, Garcia-del Portillo F, Garrido P, Gautier L, Goebel W, Gomez-Lopez N, Hain T, Hauf J, Jackson D, Jones LM, Kaerst U, Kreft J, Kuhn M, Kunst F, Kurapkat G, Madueno E, Maitournam A, Vicente JM, Ng E, Nedjari H, Nordsiek G, Novella S, de Pablos B, Perez-Diaz JC, Purcell R, Remmel B, Rose M, Schlueter T, Slimoes N, Tierrez A, Vaquez-Boland JA, Voss H, Wehland J, Cossart P (2001) Comparative genomics of Listeria species. Science 294:849–852.

    PubMed  CAS  Google Scholar 

  • Grant AJ, Farris M, Alefounder P, Williams PH, Woodward MJ, O’Connor CD (2003) Coordination of pathogenicity island expression by the BipA GTPase in enteropathogenic Escherichia coli (EPEC). Mol Microbiol 48:507–521.

    Article  PubMed  CAS  Google Scholar 

  • Hakansson S, Galyov EE, Rosqvist R, Wolf-Watz H (1996) The Yersinia YpkA Ser/Thr kinase is translocated and subsequently targeted to the inner surface of the HeLa cell plasma membrane. Mol Microbiol 20:593–603.

    Article  PubMed  CAS  Google Scholar 

  • Hershko A, Ciechanover A (1998) The ubiquitin system. Annu Rev Biochem 67:425–479.

    Article  PubMed  CAS  Google Scholar 

  • Heyninck K, Beyaert R (2005) A20 inhibits NF-kappaB activation by dual ubiquitin-editing functions. Trends Biochem Sci 30:1–4.

    Article  PubMed  CAS  Google Scholar 

  • Hiltz MF, Sisson GR, Brassinga AK, Garduño E, Garduño RA, Hoffman PS (2004) Expression of magA in Legionella pneumophila Philadelphia-1 is developmentally regulated and a marker of formation of mature intracellular forms. J Bacteriol 186:3038–3045.

    Article  PubMed  CAS  Google Scholar 

  • Hisert KB, MacCoss M, Shiloh MU, Darwin KH, Singh S, Jones RA, Ehrt S, Zhang Z, Gaffney BL, Gandotra S, Holden DW, Murray D, Nathan C (2005) A glutamate-alanine-leucine (EAL) domain protein of Salmonella controls bacterial survival in mice, antioxidant defence and killing of macrophages: role of cyclic diGMP. Mol Microbiol 56:1234–1245.

    Article  PubMed  CAS  Google Scholar 

  • Hryniewicz-Jankowska A, Czogalla A, Bok E, Sikorsk AF (2002) Ankyrins, multifunctional proteins involved in many cellular pathways. Folia Histochem Cytobiol 40:239–249.

    PubMed  CAS  Google Scholar 

  • Jacobi S, Heuner K (2003) Description of a putative type I secretion system in Legionella pneumophila. Int J Med Microbiol 293:349–358.

    Article  PubMed  CAS  Google Scholar 

  • Keane OM, Dorman CJ (2003) The gyr genes of Salmonella enterica serovar Typhimurium are repressed by the factor for inversion stimulation, Fis. Mol Genet Genomics. 270:56–65. Epub 2003 Jul 30.

    Article  PubMed  CAS  Google Scholar 

  • Kelly A, Goldberg MD, Carroll RK, Danino V, Hinton JC, Dorman CJ (2004) A global role for Fis in the transcriptional control of metabolism and type III secretion in Salmonella enterica serovar Typhimurium. Microbiology. 150:2037–2053.

    Article  PubMed  CAS  Google Scholar 

  • Klemm P, Hjerrild L, Gjermansen M, Schembri MA (2004) Structure-function analysis of the self-recognizing Antigen 43 autotransporter protein from Escherichia coli. Mol Microbiol 51:283–296.

    Article  PubMed  CAS  Google Scholar 

  • Ko KS, Hong SK, Lee HK, Park MY, Kook YH (2003a) Molecular evolution of the dotA gene in Legionella pneumophila. J Bacteriol 185:6269–6277.

    Article  CAS  Google Scholar 

  • Ko KS, Lee HK, Park MY, Kook YH (2003b) Mosaic structure of pathogenicity islands in Legionella pneumophila. J Mol Evol 57:63–72.

    Article  CAS  Google Scholar 

  • Luneberg E, Mayer B, Daryab N, Kooistra O, Zahringer U, Rohde M, Swanson J, Frosch M (2001) Chromosomal insertion and excision of a 30 kb unstable genetic element is responsible for phase variation of lipopolysaccharide and other virulence determinants in Legionella pneumophila. Mol Microbiol 39:1259–1271.

    Article  PubMed  CAS  Google Scholar 

  • Luo ZQ, Isberg RR (2004) Multiple substrates of the Legionella pneumophila Dot/Icm system identified by interbacterial protein transfer. Proc Natl Acad Sci USA 101:841–846. Epub 2004 Jan 8.

    Article  PubMed  CAS  Google Scholar 

  • Marra A, Blander SJ, Horwitz MA, Shuman HA (1992) Identification of a Legionella pneumophila locus required for intracellular multiplication in human macrophages. Proc Natl Acad Sci USA 89:9607–9611.

    Article  PubMed  CAS  Google Scholar 

  • Molofsky AB, Swanson MS (2003) Legionella pneumophila CsrA is a pivotal repressor of transmission traits and activator of replication. Mol Microbiol 50:445–461.

    Article  PubMed  CAS  Google Scholar 

  • Morozova I, Qu X, Shi S, Asamani G, Greenberg JE, Shuman HA, Russo JJ (2004) Comparative sequence analysis of the icm/dot genes in Legionella. Plasmid 51:127–147.

    Article  PubMed  CAS  Google Scholar 

  • Moskovitz J, Rahman MA, Strassman J, Yancey SO, Kushner SR, Brot N, Weissbach H (1995) Escherichia coli peptide methionine sulfoxide reductase gene: regulation of expression and role in protecting against oxidative damage. J Bacteriol 177:502–507.

    PubMed  CAS  Google Scholar 

  • Muder RR, Yu VL (2002) Infection due to Legionella species other than L. pneumophila. Clin Infect Dis 35:990–998.

    Article  PubMed  Google Scholar 

  • Nagai H, Kagan JC, Zhu X, Kahn RA, Roy CR (2002) A bacterial guanine nucleotide exchange factor activates ARF on Legionella phagosomes. Science 295:679–682.

    Article  PubMed  CAS  Google Scholar 

  • Ogata H, Renesto P, Audic S, Robert C, Blanc G, Fournier PE, Parinello H, Claverie JM, Raoult D, Galvao MA, Mafra C, Chamone CB, Calic SB, Zavala-Velazquez JE, Walker DH, Kelly PJ, Meads N, Theobald A, Fang R, Houhamdi L, Azad AF, Parola P, Sanogo OY, Lerdthusnee K, Zeaiter Z, Chauvancy G, Gonzalez JP, Miller RS, Telford SR, 3rd, Wongsrichanalai C, McDaniel P, Rolain JM, Franc M, Davoust B, La Scola B, Meconi S, Fenollar F, Roux V, Stuhl L, Maurin M, Richter J, Petridou J, Haussinger D, Enea M, de Lamballerie X (2005) The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite. PLoS Biol 3:e248. Epub 2005 Jul 5.

    Article  PubMed  CAS  Google Scholar 

  • Osuna R, Lienau D, Hughes KT, Johnson RC (1995) Sequence, regulation, and functions of fis in Salmonella typhimurium. J Bacteriol. 177:2021–2032.

    PubMed  CAS  Google Scholar 

  • Rankin S, Li Z, Isberg RR (2002) Macrophage-induced genes of Legionella pneumophila: protection from reactive intermediates and solute imbalance during intracellular growth. Infect Immun 70:3637–3648.

    Article  PubMed  CAS  Google Scholar 

  • Reiss U, Oskouian B, Zhou J, Gupta V, Sooriyakumaran P, Kelly S, Wang E, Merrill AHJ, Saba JD (2004) Sphingosine-phosphate lyase enhances stress-induced ceramide generation and apoptosis. J Biol Chem 279:1281–1290.

    Article  PubMed  CAS  Google Scholar 

  • Ridenour DA, Cirillo SL, Feng S, Samrakandi MM, Cirillo JD (2003) Identification of a gene that affects the efficiency of host cell infection by Legionella pneumophila in a temperature-dependent fashion. Infect Immun 71:6256–6263.

    Article  PubMed  CAS  Google Scholar 

  • Rossier O, Cianciotto NP (2001) Type II protein secretion is a subset of the PilD-dependent processes that facilitate intracellular infection by Legionella pneumophila. Infect Immun 69:2092–2098.

    Article  PubMed  CAS  Google Scholar 

  • Rossier O, Cianciotto NP (2005) The Legionella pneumophila tatB gene facilitates secretion of phospholipase C, growth under iron-limiting conditions, and intracellular infection. Infect Immun 73:2020–2032.

    Article  PubMed  CAS  Google Scholar 

  • Rudnick PA, Arcondeguy T, Kennedy CK, Kahn D (2001) glnD and mviN are genes of an essential operon in Sinorhizobium meliloti. J Bacteriol 183:2682–2685.

    Article  PubMed  CAS  Google Scholar 

  • Sauer JD, Bachman MA, Swanson MS (2005) The phagosomal transporter A couples threonine acquisition to differentiation and replication of Legionella pneumophila in macrophages. Proc Natl Acad Sci USA 102:9924–9929.

    Article  PubMed  CAS  Google Scholar 

  • Segal G, Russo JJ, Shuman HA (1999) Relationships between a new type IV secretion system and the icm/dot virulence system of Legionella pneumophila. Mol Microbiol 34:799–809.

    Article  PubMed  CAS  Google Scholar 

  • Segal G, Feldman M, Zusman T (2005) The Icm/Dot type-IV secretion systems of Legionella pneumophila and Coxiella burnetii. FEMS Microbiol Rev. 29:65–81.

    Article  PubMed  CAS  Google Scholar 

  • Seshadri R, Paulsen IT, Eisen JA, Read TD, Nelson KE, Nelson WC, Ward NL, Tettelin H, Davidsen TM, Beanan MJ, Deboy RT, Daugherty SC, Brinkac LM, Madupu R, Dodson RJ, Khouri HM, Lee KH, Carty HA, Scanlan D, Heinzen RA, Thompson HA, Samuel JE, Fraser CM, Heidelberg JF (2003) Complete genome sequence of the Q-fever pathogen Coxiella burnetii. Proc Natl Acad Sci USA 100:5455–5460. Epub 2003 Apr 18.

    Article  PubMed  CAS  Google Scholar 

  • Sheikh J, Hicks S, Dall’Agnol M, Phillips AD, Nataro JP (2001) Roles for Fis and YafK in biofilm formation by enteroaggregative Escherichia coli. Mol Microbiol 41:983–997.

    Article  PubMed  CAS  Google Scholar 

  • Simm R, Morr M, Kader A, Nimtz M, Romling U (2004) GGDEF and EAL domains inversely regulate cyclic di-GMP levels and transition from sessility to motility. Mol Microbiol 53:1123–1134.

    Article  PubMed  CAS  Google Scholar 

  • Skaar EP, Tobiason DM, Quick J, Judd RC, Weissbach H, Etienne F, Brot N, Seifert HS (2002) The outer membrane localization of the Neisseria gonorrhoeae MsrA/B is involved in survival against reactive oxygen species. Proc Natl Acad Sci USA 99:10108–10113.

    Article  PubMed  CAS  Google Scholar 

  • Soderberg MA, Rossier O, Cianciotto NP (2004) The type II protein secretion system of Legionella pneumophila promotes growth at low temperatures. J Bacteriol 186:3712–3720.

    Article  PubMed  CAS  Google Scholar 

  • Stover CK, Pham XQ, Erwin AL, Mizoguchi SD, Warrener P, Hickey MJ, Brinkman FS, Hufnagle WO, Kowalik DJ, Lagrou M, Garber RL, Goltry L, Tolentino E, Westbrock-Wadman S, Yuan Y, Brody LL, Coulter SN, Folger KR, Kas A, Larbig K, Lim R, Smith K, Spencer D, Wong GK, Wu Z, Paulsen IT, Reizer J, Saier MH, Hancock RE, Lory S, Olson MV. (2000) Complete genome sequence of Pseudomonas aeruginosa PA01, an opportunistic pathogen. Nature 406:959–64.

    Article  PubMed  CAS  Google Scholar 

  • Swanson MS, Fernandez-Moreira E (2002) A microbial strategy to multiply in macrophages: the pregnant pause. Traffic 3:170–177.

    Article  PubMed  CAS  Google Scholar 

  • Tal R, Wong HC, Calhoon R, Gelfand D, Fear AL, Volman G, Mayer R, Ross P, Amikam D, Weinhouse H, Cohen A, Sapir S, Ohana P, Benziman M (1998) Three cdg operons control cellular turnover of cyclic di-GMP in Acetobacter xylinum: genetic organization and occurrence of conserved domains in isoenzymes. J Bacteriol 180:4416–4425.

    PubMed  CAS  Google Scholar 

  • Vogel JP, Andrews HL, Wong SK, Isberg RR (1998) Conjugative transfer by the virulence system of Legionella pneumophila. Science 279:873–876.

    Article  PubMed  CAS  Google Scholar 

  • Walburger A, Koul A, Ferrari G, Nguyen L, Prescianotto-Baschong C, Huygen K, Klebl B, Thompson C, Bacher G, Pieters J (2004) Protein Kinase G from Pathogenic Mycobacteria Promotes Survival Within Macrophages. Science DOI: 10.1126/science.1099384.

    Google Scholar 

  • Wu M, Sun LV, Vamathevan J, Riegler M, Deboy R, Brownlie JC, McGraw EA, Martin W, Esser C, Ahmadinejad N, Wiegand C, Madupu R, Beanan MJ, Brinkac LM, Daugherty SC, Durkin AS, Kolonay JF, Nelson WC, Mohamoud Y, Lee P, Berry K, Young MB, Utterback T, Weidman J, Nierman WC, Paulsen IT, Nelson KE, Tettelin H, O’Neill SL, Eisen JA (2004) Phylogenomics of the Reproductive Parasite Wolbachia pipientis wMel: A Streamlined Genome Overrun by Mobile Genetic Elements. PLoS Biol 2:E69.

    Article  PubMed  Google Scholar 

  • Yu VL, Plouffe JF, Pastoris MC, Stout JE, Schousboe M, Widmer A, Summersgill J, File T, Health CM, Paterson DL, Chereshsky A (2002) Distribution of Legionella species and serogroups isolated by culture in patients with sporadic community-acquired legionellosis: an international collaborative survey. J Infect Dis 186:127–128.

    Article  PubMed  Google Scholar 

  • Yuste L, Hervas AB, Canosa I, Tobes R, Jimenez JI, Nogales J, Perez-Perez MM, Santero E, Diaz E, Ramos JL, de Lorenzo V, Rojo F (2006) Growth phase-dependent expression of the Pseudomonas putida KT2440 transcriptional machinery analysed with a genome-wide DNA microarray. Environ Microbiol 8:165–77.

    Article  PubMed  CAS  Google Scholar 

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Cazalet, C., Buchrieser, C. (2008). Legionella pneumophila Pathogenesis: Lessons Learned from Genomics. In: Legionella pneumophila. Infectious Diseases And Pathogenesis. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-70896-6_1

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