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Neuron-Glia Interaction in Homeostasis of the Neurotransmitters Glutamate and GABA

  • Arne Schousboe
  • Helle S. Waagepetersen

The functional activity in the brain is primarily composed of interplay between excitation and inhibition. In any given region the output is based upon a complex processing of incoming signals that require both excitatory and inhibitory units. Moreover, these units must be regulated and balanced such that an integrated and finely tuned response is generated. In each of these units or synapses, the activity depends on biosynthesis, release, receptor interaction, and inactivation of the neurotransmitters; thus, it is easily understood that each of these processes needs to be highly regulated and controlled.

Keywords

Glutamine Synthetase Glutamate Transporter Glutamate Uptake Glutamatergic Neuron Gaba Transporter 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  • Arne Schousboe
    • 1
  • Helle S. Waagepetersen
    • 1
  1. 1.Dept. PharmacolDanish Univ. Pharm. Sci.CopenhagenDenmark

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