Subventricular Zone Cells as a Tool for Brain Repair

  • Fabienne Agasse
  • Liliana Bernardino
  • João O. Malva

Neural stem cells of the adult subventricular zone (SVZ) can be easily propagated in culture and give rise to a large number of glial cells and neuronal progenitors, offering promising perspectives for future cell-based therapies. Many factors able to modulate neuronal production have been identified but efficient differentiation into specific neuronal phenotypes is still a challenge. Animal models of brain diseases have been used in neuronal replacement studies in Huntington’s and Parkinson’s diseases, in stroke and trauma, contributing to highlight the potential of stem cell’s therapy.


Vascular Endothelial Growth Factor Olfactory Bulb Dentate Gyrus Neural Stem Cell Subventricular Zone 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  • Fabienne Agasse
    • 1
  • Liliana Bernardino
    • 1
  • João O. Malva
    • 2
  1. 1.New England Inflammation and Tissue Protection InstituteNortheastern UniversityBostonUSA
  2. 2.Center for Neuroscience and Cell Biology, Institute of Biochemistry, Faculty of MedicineUniversity of CoimbraPortugal

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