All the major neurodegenerative diseases are characterised by the accumulation of proteinaceous aggregates within neurons. The commonest of such conditions, Alzheimer’s disease, also features extracellular proteinaceous aggregates (amyloid). The role of these aggregates in the aetiology and progression of cognitive impairment is still unclear, but their absence in young adults suggests that their removal would at any rate not be harmful.
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Grey, A.D.N.J.d. (2007). Rejuvenating Neurons and Glia with Microbial Enzymes. In: Malva, J.O., Rego, A.C., Cunha, R.A., Oliveira, C.R. (eds) Interaction Between Neurons and Glia in Aging and Disease. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-70830-0_23
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