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Adult Neurogenesis in Neurodegenerative Diseases

  • Tomas Deierborg
  • Jia- Yi Li
  • Patrik Brundin

Neurogenesis occurs in the adult hippocampus and subventricular zone. It provides an exciting potential inroad to new treatments for slow neurodegenerative disorders. Changes in neurogenesis in human degenerative diseases may also teach us something about the underlying disease mechanisms. In the present chapter, we review data from clinical and experimental studies concerning neurogenesis in Alzheimer’s, Huntington’s and Parkinson’s diseases. In brief, the clinical data have not clearly shown whether the rate of neurogenesis is changed by the pathogenesis in these three diseases. Whether neurogenesis occurs at all in the adult substantia nigra under baseline conditions remains controversial. Studies on animal models of the three neurodegenerative conditions provide a mixed picture, with disease/ damage to the brain being associated both decreases and increases in neurogenesis in the different studied brain regions. In conclusion, this exciting research field is still in its infancy. It is too early to say whether neurogenesis in the adult brain can be targeted by novel therapies and be used to reduce functional deficits in slow neurodegenerative diseases.

Keywords

Substantia Nigra Dentate Gyrus Neural Stem Cell Adult Neurogenesis Hippocampal Neurogenesis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  • Tomas Deierborg
    • 1
  • Jia- Yi Li
    • 1
  • Patrik Brundin
    • 1
  1. 1.Neuronal Survival Unit, Wallenberg Neuroscience Center, Dep. Experimental Medical SienceLund UniversitySweden

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