Glia and Hippocampal Neurogenesis in the Normal, Aged and Epileptic Brain

  • William P. Gray
  • Alexandra Laskowski

In this chapter, we review the role of glial cells in hippocampal neurogenesis under normal conditions, in aging and in the epileptic brain. Astrocytes or astrocyte-like cells are emerging as key components of the neurogenic niche in health and disease, with roles ranging from being stem cells to regulating almost all aspects of neurogenesis and synaptic integration of the newly generated neurons. It is likely that astrocytes and microglial cells are key sensors of local environmental changes, modulating neurogenesis appropriately. This is likely to be a fruitful area of research for extending our understanding of the role of stem cells in the normal and diseased brain.


Granule Cell Dentate Gyrus Neural Stem Cell Temporal Lobe Epilepsy Adult Neurogenesis 


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Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  • William P. Gray
    • 1
  • Alexandra Laskowski
    • 1
  1. 1.Division of Clinical NeurosciencesUniversity of SouthamptonBassett Crescent EastUK

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