Metal Ions and Alzheimer's Disease

  • Paul A. Adlard
  • Ashley I. Bush

The role of metal ions in the evolution and progression of Alzheimer’s disease (AD) is becoming increasingly apparent. Indeed, the interactions of age-associated increases in metals with the amyloid precursor protein (APP) and its proteolytic enzymes and subsequent proteolytic fragments (such as -amyloid (A )) are well characterized. Likewise, the metal associated and age-related formation of free radicals, the subsequent generation of oxidative stress and its interactions on process whose dysfunction may contribute to the development of AD have also been highly characterized. Metal dyshomeostasis may thus initiate, and propogate, the development of AD. As science continues to gain greater resolution into the molecular underpinnings of AD, the potential for the use of metal-modulation in the treatment of this disorder is gaining greater acceptance.


Inductively Couple Plasma Mass Spectrometry Mild Cognitive Impairment Amyloid Precursor Protein Cerebral Amyloid Angiopathy Copper Level 
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Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  • Paul A. Adlard
    • 1
  • Ashley I. Bush
    • 2
  1. 1.The Oxidation Disorders LaboratoryThe Mental Health Research Institute of VictoriaParkvilleAustralia
  2. 2.Genetics and Aging Research UnitMassachusetts General HospitalCharlestownUSA

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