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Inflammation and Neuronal Susceptibility to Excitotoxic Cell Death

  • João O. Malva
  • Liliana Bernardino

The fast growing research field of Neuroinflammation is challenging the traditional view of the Brain as an immune privileged organ. Our increasing understanding of the mechanisms involved in the close functional interaction between neurons and glia in health and disease is contributing to shed new light into the cellular and molecular mechanisms of neurodegeneration. The response of microglia and astrocytes to injury, releasing signaling molecules (specially, cytokines, chemokines, growth factors, reactive oxygen and nitrogen species), is central in neuroinflammation and in neuron death/survival.

Keywords

Major Histocompatibility Complex Microglial Cell Receptor Interact Protein Central Nervous System Parenchyma Organotypic Hippocampal Slice Culture 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  • João O. Malva
    • 1
  • Liliana Bernardino
  1. 1.Center for Neuroscience and Cell Biology, Institute of Biochemistry, Faculty of MedicineUniversity of CoimbraPortugal

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