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Genetic determinants of respiratory phenotypes in mice

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Genetic Basis for Respiratory Control Disorders
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References

  1. Bonora M, Bernaudin JF, Guernier C, Brahimi-Horn MC (2004) Ventilatory responses to hypercapnia and hypoxia in conscious cystic fibrosis knockout mice Cftr-/-. Pediatr Res 55: 738-746

    Article  PubMed  Google Scholar 

  2. Chen JC, Mannino DM (1999) Worldwide epidemiology of chronic obstructive pulmonary disease. Curr Opin Pulm Med 5: 93-99

    Article  PubMed  CAS  Google Scholar 

  3. Coss-Bu JA, Walding DL, David YB, Jefferson LS (2003) Dead space ventilation in critically ill children with lung injury. Chest 123: 2050-2056

    Article  PubMed  Google Scholar 

  4. De Sanctis GT, Merchant M, Beier DR, Dredge RD, Grobholz JK, Martin TR, Lander ES, Drazen JM (1995) Quantitative locus analysis of airway hyperresponsiveness in A/J and C57BL/6J mice. Nat Genet 11: 150-154

    Article  PubMed  Google Scholar 

  5. De Sanctis GT, Singer JB, Jiao A, Yandava CN, Lee YH, Haynes TC, Lander ES, Beier DR, Drazen JM (1999) Quantitative trait locus mapping of airway responsiveness to chromosomes 6 and 7 in inbred mice. Am J Physiol 277: L1118-L1123

    PubMed  Google Scholar 

  6. Douglas NJ, Luke M, Mathur R (1993) Is the sleep apnoea/hypopnoea syndrome inherited? Thorax 48: 719-721

    PubMed  CAS  Google Scholar 

  7. Douglas NJ, White DP, Weil JV, Pickett CK, Zwillich CW (1982) Hypercapnic ventilatory response in sleeping adults. Am Rev Respir Dis 126: 758-762

    PubMed  CAS  Google Scholar 

  8. Ewart SL, Mitzner W, DiSilvestre DA, Meyers DA, Levitt RC (1996) Airway hyperresponsiveness to acetylcholine: segregation analysis and evidence for linkage to murine chromosome 6. Am J Respir Cell Mol Biol 14: 487-495

    PubMed  CAS  Google Scholar 

  9. Fleetham JA, Arnup ME, Anthonisen NR (1984) Familial aspects of ventilatory control in patients with chronic obstructive pulmonary disease. Am Rev Respir Dis 129: 3-7

    PubMed  CAS  Google Scholar 

  10. Gold AR, Schwartz AR, Wise RA, Smith PL (1993) Pulmonary function and respiratory chemosensitivity in moderately obese patients with sleep apnea. Chest 103: 1325-1329

    PubMed  CAS  Google Scholar 

  11. Gothe B, Altose MD, Goldman MD, Cherniack NS (1981) Effect of quiet sleep on resting and CO2-stimulated breathing in humans. J Appl Physiol 50: 724-730

    PubMed  CAS  Google Scholar 

  12. Gould GA, Whyte KF, Rhind GB, Airlie MA, Catterall JR, Shapiro CM, Douglas NJ. The sleep hypopnea syndrome (1988) Am Rev Respir Dis 137: 895-898

    PubMed  CAS  Google Scholar 

  13. Higgins M. Risk factors associated with chronic obstructive lung disease (1991) Ann N Y Acad Sci 624: 7-17

    Article  PubMed  CAS  Google Scholar 

  14. Huang K, Rabold R, Schofield B, Mitzner W, Tankersley CG (2007) Age-dependent changes of airway and lung parenchyma in C57Bl/6J mice. J Appl Physiol 102: 200-206

    Article  PubMed  Google Scholar 

  15. Hudgel DW, Weil JV (1974) Asthma associated with decreased hypoxic ventilatory drive. A family study. Ann Intern Med 80: 623-625

    PubMed  CAS  Google Scholar 

  16. Hudgel DW, Weil JV (1975) Depression of hypoxic and hypercapnic ventilatory drives in severe asthma. Chest 68: 493-497

    PubMed  CAS  Google Scholar 

  17. Jeffrey AA, Warren PM, Flenley DC (1992) Acute hypercapnic respiratory failure in patients with chronic obstructive lung disease: risk factors and use of guidelines for management. Thorax 47: 34-40

    PubMed  CAS  Google Scholar 

  18. Kaufman BJ, Ferguson MH, Cherniack RM (1959) Hypoventilation in obesity. J Clin Invest 38: 500-507

    Article  PubMed  CAS  Google Scholar 

  19. Kawakami Y, Irie T, Kishi F, Asanuma Y, Shida A, Yoshikawa T, Kamishima K, Hasegawa H, Murao M (1981) Familial aggregation of abnormal ventilatory control and pulmonary function in chronic obstructive pulmonary disease. Eur J Respir Dis 62: 56-64

    PubMed  CAS  Google Scholar 

  20. Kawakami Y, Irie T, Shida A, Yoshikawa T (1982) Familial factors affecting arterial blood gas values and respiratory chemosensitivity in chronic obstructive pulmonary disease. Am Rev Respir Dis 125: 420-425

    PubMed  CAS  Google Scholar 

  21. Kikuchi Y, Okabe S, Tamura G, Hida W, Homma M, Shirato K, Takishima T (1994) Chemosensitivity and perception of dyspnea in patients with a history of near-fatal asthma. N Engl J Med 330: 1329-1334

    Article  PubMed  CAS  Google Scholar 

  22. Kinkead R, LeBlanc M, Gulemetova R, Lalancette-Hebert M, Lemieux M, Mandeville I, Jeannotte L (2004) Respiratory adaptations to lung morphological defects in adult mice lacking Hoxa5 gene function. Pediatr Res 56: 553-562

    Article  PubMed  CAS  Google Scholar 

  23. Kinney JM, Askanazi J, Gump FE, Foster RJ, Hyman AI (1980) Use of the ventilatory equivalent to separate hypermetabolism from increased dead space ventilation in the injured or septic patient. J Trauma 20: 111-119

    Article  PubMed  CAS  Google Scholar 

  24. Levitt RC, Mitzner W (1989) Autosomal recessive inheritance of airway hyperreactivity to 5-hydroxytryptamine. J Appl Physiol 67: 1125-1132

    PubMed  CAS  Google Scholar 

  25. Levitt RC, Mitzner W, Kleeberger SR (1990) A genetic approach to the study of lung physiology: understanding biological variability in airway responsiveness. Am J Physiol 258: L157-L164

    PubMed  CAS  Google Scholar 

  26. Marin JM, Montes de Oca M, Rassulo J, Celli BR (1999) Ventilatory drive at rest and perception of exertional dyspnea in severe COPD. Chest 115: 1293-1300.

    Article  PubMed  CAS  Google Scholar 

  27. McFadden ERJ (1991) Fatal and near-fatal asthma. N Engl J Med 324: 409-411

    Article  PubMed  Google Scholar 

  28. Montes de Oca M, Celli BR (1998) Mouth occlusion pressure, CO2 response and hypercapnia in severe chronic obstructive pulmonary disease. Eur Respir J 12: 666-671

    Article  PubMed  CAS  Google Scholar 

  29. Mountain RC, Zwillich CW, Weil JV (1978) Hypoventilation in obstructive lung disease; the role of familial factors. N Engl J Med 298: 512-525

    Article  Google Scholar 

  30. Prabhakar NR, Mitra J, Adams EM, Cherniack NS (1989) Involvement of ventral medullary surface in respiratory responses induced by 2,4-dinitrophenol. J Appl Physiol 66: 598-605

    PubMed  CAS  Google Scholar 

  31. Redline S, Leitner J, Arnold J, Tishler PV, Altose MD (1997) Ventilatory-control abnormalities in familial sleep apnea. Am J Respir Crit Care Med 156: 155-160

    PubMed  CAS  Google Scholar 

  32. Reinhard C, Eder G, Fuchs H, Ziesenis A, Heyder J, Schulz H (2002) Inbred strain variation in lung function. Mamm Genome 13: 429-437

    Article  PubMed  Google Scholar 

  33. Reinhard C, Meyer B, Fuchs H, Stoeger T, Eder G, Ruschendorf F, Heyder J, Nurnberg P, de Angelis MH, Schulz H (2005) Genomewide linkage analysis identifies novel genetic Loci for lung function in mice. Am J Respir Crit Care Med 171: 880-888

    Article  PubMed  Google Scholar 

  34. Rosen RL (1986) Acute respiratory failure and chronic obstructive lung disease. Med Clin North Am 70: 895-907.

    PubMed  CAS  Google Scholar 

  35. Schlenker EH, Hansen SN, Pfaff DW (2002) Gender comparisons of control of breathing and metabolism in conscious mice exposed to cold. Neuroendocrinology 76: 381-389

    Article  PubMed  CAS  Google Scholar 

  36. Schneider H, Patil SP, Canisius S, Gladmon EA, Schwartz AR, O’donnell CP, Smith PL, Tankersley CG (2003) Hypercapnic duty cycle is an intermediate physiological phenotype linked to mouse chromosome 5. J Appl Physiol 95: 1119

    Google Scholar 

  37. Schulz H, Johner C, Eder G, Ziesenis A, Reitmeier P, Heyder J, Balling R (2002) Respiratory mechanics in mice: strain and sex specific differences. Acta Physiol Scand 174: 367-375

    Article  PubMed  CAS  Google Scholar 

  38. Shea SA, Guz A (1992) Personnalitè ventilatoire : an overview. Respir Physiol 87: 275-291

    Article  PubMed  CAS  Google Scholar 

  39. Sorli J, Grassino A, Lorange G, Milic-Emili J (1978) Control of breathing in patients with chronic obstructive lung disease. Clin Sci Mol Med 54: 295-304

    PubMed  CAS  Google Scholar 

  40. Soutiere SE, Tankersley CG (2001) Challenges implicit to gene discovery research in the control of ventilation during hypoxia. High Alt Med Biol 2: 191-200

    Article  PubMed  CAS  Google Scholar 

  41. Soutiere SE, Tankersley CG, Mitzner W (2004) Differences in alveolar size in inbred mouse strains. Respir Physiol Neurobiol 140: 283-291

    Article  PubMed  Google Scholar 

  42. Tankersley CG (2001) Selected Contribution: Variation in acute hypoxic ventilatory response is linked to mouse chromosome 9. J Appl Physiol 90: 1615-1622

    PubMed  CAS  Google Scholar 

  43. Tankersley CG, Broman KW (2004) Interactions in hypoxic and hypercapnic breathing are genetically linked to mouse chromosomes 1 and 5. J Appl Physiol 97: 77-84

    Article  PubMed  Google Scholar 

  44. Tankersley CG, DiSilvestre DA, Jedlicka AE, Wilkins HM, Zhang L (1998) Differential inspiratory timing is genetically linked to mouse chromosome J Appl Physiol 85: 360-365

    PubMed  CAS  Google Scholar 

  45. Tankersley CG, Elston RC, Schnell AH (2000) Genetic determinants of acute hypoxic ventilation: patterns of inheritance in mice. J Appl Physiol 88: 2310-2318

    PubMed  CAS  Google Scholar 

  46. Tankersley CG, Fitzgerald RS, Kleeberger SR (1994) Differential control of ventilation among inbred strains of mice. Am J Physiol 267: R1371-R1377

    PubMed  CAS  Google Scholar 

  47. Tankersley CG, Fitzgerald RS, Levitt RC, Mitzner WA, Ewart SL, Kleeberger SR (1997) Genetic control of differential baseline breathing pattern. J Appl Physiol 82: 874-881

    PubMed  CAS  Google Scholar 

  48. Tankersley CG, Haenggeli C, Rothstein JD (2007) Respiratory impairment in a mouse model of amyotrophic lateral sclerosis. J Appl Physiol 102: 926-932

    Article  PubMed  Google Scholar 

  49. Tankersley CG, Kulaga H, Wang MM (2001) Inspiratory timing differences and regulation of Gria2 gene variation: a candidate gene hypothesis. Adv Exp Med Biol 499: 477-482

    PubMed  CAS  Google Scholar 

  50. Tankersley CG, Rabold R, Mitzner W (1999) Differential lung mechanics are genetically determined in inbred murine strains. J Appl Physiol 86: 1764-1769

    PubMed  CAS  Google Scholar 

  51. Zwillich CW, Sutton FD, Pierson DJ, Greagh EM, Weil JV (1975) Decreased hypoxic ventilatory drive in the obesity-hypoventilation syndrome. Am J Med 59: 343-348

    Article  PubMed  CAS  Google Scholar 

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Tankersley, C.G. (2008). Genetic determinants of respiratory phenotypes in mice. In: Genetic Basis for Respiratory Control Disorders. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-70765-5_10

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