Vascular Cognitive Impairment
Vascular Cognitive Impairment or VCI can be compared to the proverbial blind men palpating the elephant. Sometimes the “parts” appear to be diverse and disparate. Thus, VCI tends to mean different things to different people. Despite this diversity of opinions, the study of vascular brain disease has a long and quite distinguished history in neurology.
A fundamental issue regarding mild cognitive impairment associated with vascular disease is the ultimate relationship of VCI to vascular dementia (VaD). Here is when a simple palpation of the “parts” may cause confusion. In this chapter we do not necessarily draw a definitive line that separates VCI from VaD. The exact relationship between these entities is a work in progress. Nonetheless, it is very clear that VCI and VaD are opposite sides of the same coin.
This chapter will be divided into five parts. First, we present a short historical perspective of vascular disease as related to VCI. The second part of this chapter...
KeywordsPulse Wave Velocity Executive Control Carotid Stenosis Vascular Cognitive Impairment Information Processing Speed
- Bowler, J. V., & Hachinski, V. (1995). Vascular cognitive impairment: A new approach to vascular dementia. In Bailliere’s clinical neurology, 4, 357–376.Google Scholar
- Di Carlo, A., Baldereschi, M., Amaducci, L., Maggi, S., Grigoletto, F., Scarlato, G., et al. (2000). Cognitive impairment without dementia in older people: prevalence, vascular risk factors, impact on disability. The Italian longitudinal study on aging.Journal of the American Geriatrics Society, 48, 775–782.PubMedGoogle Scholar
- Garrett K. D., Browndyke J. N., Whelihan W., Paul R. H., DiCarlo M., Moser D. J., et al. (2004). The neuropsychological profile of vascular cognitive impairment – no dementia: Comparisons to patients at risk for cerebrovascular disease and vascular dementia. Archives of Clinical Neuropsychology, 19, 745–757.PubMedCrossRefGoogle Scholar
- Hauw, J. J. (1995). The history of lacunes. In G. A. Donnan, B. Norrving, J. M. Bamford, & J. Bogousslavsky (Eds.), Lacunar and other subcortical infarctions (pp.3–15).New York, NY: Oxford University Press.Google Scholar
- Johnston, S. C., O’Meara, E. S., Manolio, T. A., Lefkowitz, D., O’Leary, D. H., Goldstein, S., et al. (2004). Cognitive impairment and decline are associated with carotid artery disease in patients without clinically evident cerebrovascular disease. Annals of Internal Medicine, 140, 237–247.PubMedGoogle Scholar
- Lamar, M., Price, C. C., Libon, D. J., Penney, D. L., Kaplan, E., Grossman, M. et al. (2007). Alterations in working memory as a function of leukoaraiosis in dementia. Neuropsychologia, 45, 245–254.Google Scholar
- Libon, D. J., Bogdanoff, B., Cloud, B. S., Skalina, S., Carew, T. G., Gitlin, H. L. et al. (1998). Motor learning and qualitative measures of the hippocampus and subcortical white alterations in Alzheimer’s disease and ischemic vascular dementia. Journal of Clinical and Experimental Neuropsychology, 20, 30–41.PubMedCrossRefGoogle Scholar
- Meyer, J., Xu, G., Thomby, J., Chowdhury, M., & Quach, M. (2002). Longitudinal analysis of abnormal domains comprising mild cognitive impairment (MCI) during aging. Journal of Neuroscience, 201, 19–25.Google Scholar
- Rockwood, K., Davis, H., MacKnight, C., Vandorpe, R., Gauthier, S., Guzman, A., et al. (2004). The consortium to investigate vascular impairment of cognition: methods and first findings. Canadian Journal of Neurological Sciences, 30, 237–243.Google Scholar
- Roman, G. C. (2004).Vascular dementia: advances in nosology, diagnosis, treatment and prevention. Panminerva Medical, 46, 207–215.Google Scholar
- Roman, G. C., Sachdev, P., Royall, D. R., Bullock, R. A., Orgogozo, J. M., Lopez-Pousa, S., et al. (2004). Vascular cognitive disorder: a new diagnostic category updating vascular cognitive impairment and vascular dementia.Journal of the Neurological Sciences, 226, 81–87.PubMedCrossRefGoogle Scholar
- Sacuiu, S. Sjogren, M., Johansson, B., Gustafson, D., & Skoog, I. (2005). Prodromal cognitive signs of dementia in 85-year-olds using four sources of information. Neurology, 65, 1894–1900.Google Scholar
- Stephens, S., Kenny, R. A., Rowan, E., Kalaria, R. N., Bradbury, M., Pearce, R., et al. (2005). Association between mild vascular cognitive impairment and impaired activities of daily living in older stroke survivors without dementia. Journal of the American Geriatric Society, 53, 103–107.CrossRefGoogle Scholar
- Tervo, S., Kivipelto, M., Hanninen, T., Vanhanen, M., Hallikainen, M., Mannermaa, A. et al. (2004). Incidence and risk factors for mild cognitive impairment: a population-based three-year follow-up study of cognitively healthy elderly subjects. Dementia and Geriatric Cognitive Disorders, 17, 196–203.PubMedCrossRefGoogle Scholar
- van Harten, B., Laman, D. M., van Duijn, H., Knol, D. L., Stam, C. J., Scheltens, P. et al. (2006). The auditory oddball paradigm in patients with vascular cognitive impairment: a prolonged latency of the N2 complex. Dementia and Geriatric Cognitive Disorders, 21, 322–327.PubMedCrossRefGoogle Scholar
- van den Heuvel, D. M. J., ten Dam, V. H., de Craen, A. J. M., Admiraal-Behloul, F., Olofsen, H., Bollen, E. L. E. M., et al. (2006). Increase in periventricular white matter hyperintensities parallels decline in mental processing speed in a non-demented elderly population. Journal of Neurology, Neurosurgery, and Psychiatry, 77, 149–153.PubMedCrossRefGoogle Scholar
- Waite, L. M., Grayson, D. A., Piguet, O., Creasey, H., Bennett, H. P., & Broe, G. A. (2005). Gait slowing as a predictor of incident dementia: 6-year longitudinal data from the Sydney Older Persons Study. Journal of the Neurological Sciences, 229–230, 89–93.Google Scholar