Neurovascular Geography and Mapping the Consequences of Its Injury
As with any organ in the body, the brain depends upon the integrity of its blood supply to maintain normal function. Despite the fact that it only constitutes about 2% of body weight, however, it needs about 20% of the cardiac output and a comparable proportion of the total amount of oxygen used by the body. To understand the cognitive and behavioral consequences of an interruption of normal blood flow, it is important to provide first a general description of the geography of the cerebral circulatory system. The purpose of this chapter is to provide this overview and then to describe the diagnostic tools that reveal the effects of diseases and conditions that disrupt supply. For a more detailed anatomical description of this system and investigative modalities, the reader is referred to Stroke: Pathophysiology, Diagnosis and Management (Mohr, Choi, Grotta, Weir, & Wolf, 2004).
The brain is fed by two main arterial sources: the internal carotid arteries and the...
KeywordsSingle Photon Emission Compute Tomography Internal Carotid Artery Diffusion Tensor Imaging Magnetic Resonance Angiography Vertebral Artery
- Chalela, J. A., Kidwell, C. S., Nentwich, L. M., Luby, M., Butman, J. A., Demchuk, A. M., et al. (2007). Magnetic resonance imaging and computed tomography in emergency assessment of patients with suspected acute stroke: a prospective comparison. Lancet, 369 (9558), 293–298.PubMedCrossRefGoogle Scholar
- Mohr, J. P., Choi, D. W., Grotta, J. C., Weir, B., & Wolf, P. A. (2004). Stroke: Pathophysiology, diagnosis, and management (4th ed.). New York: Churchill Livingston.Google Scholar
- Mohr, J. P., Lazar, R. M., Marshall, R. S., & Hier, D. B. (2004). Middle cerebral artery disease. In J. P. Mohr, D. W. Choi, J. C. Grotta, B. Weir, & P. A. Wolf (Eds.), Stroke: pathophysiology, diagnosis, and management (4th ed.). New York: Churchill-Livingston.Google Scholar
- Williams, J. P., & Snow, R. D. (1995). Brain Imaging. In J. P. Mohr & J. C. Gautier (Eds.), Guide to Clinical Neurology (pp. 127–146.). New York: Churchill-Livingstone.Google Scholar
- Zazulia, A. R., Markham, J., & Power, W. J. (2004). Cerebral blood flow and metabolism in human cerebrovascular disease. In J. P. Mohr, D. W. Choi, J. C. Grotta, B. Weir, & P. A. Wolf (Eds.), Stroke: Pathophysiology, Diagnosis, and Management (4th ed., pp. 799–819). New York: Churchill-Livingston.Google Scholar