Cognition After Cardiac Surgery

  • Ola A. Selnes
  • Rebecca F. Gottesman


Cardiopulmonary bypass (CPB) was introduced more than five decades ago, and although there has been a dramatic reduction in both morbidity and mortality associated with this procedure, both short- and long-term cognitive impairment after coronary artery bypass grafting (CABG) continue to be significant concerns. The search for the etiology of these adverse neurocognitive outcomes has focused mainly on procedure-related factors such as embolic injury and hypoperfusion, but more recent studies have also considered patient-related factors, in particular the overall vascular burden of the patient’s brain before surgery.

Progress in our understanding of the cognitive consequences of the use of CPB has been slow for several reasons. First, the technology of CPB has been continuously evolving since its introduction, and results of studies published more than 10 years ago are therefore less applicable to the way in which CABG is being performed today. Second, the patient...


Coronary Artery Bypass Grafting Cognitive Decline Coronary Artery Bypass Grafting Patient Postoperative Atrial Fibrillation Coronary Artery Bypass Grafting Group 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



This research was supported by grant 35610 from the National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD and by the Dana Foundation, New York, NY, and the Johns Hopkins Medical Institutions GCRC grant RR 00052.

We also thank the staff and participants in our study and Dr. Talalay for her editorial assistance. We are also grateful for the ongoing collaboration with Dr. W. Baumgartner as well as other participating cardiac surgeons and cardiologists.


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© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  1. 1.NeurologyDivision of Cognitive NeuroscienceBaltimoreUSA

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