Physiological Roles and Mechanisms of Signaling by TRAF2 and TRAF5

  • Ping-Yee Billie Au
  • Wen-Chen Yeh
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 597)


TRAF2 and TRAF5 are closely related members of the TRAF family of proteins. They are important signal transducers for a wide range of TNF receptor superfamily members, including TNFR1, TNFR2, CD40 and other lymphocyte costimulatory receptors, RANK/TRANCE-R, EDAR, LTβR, LMP-1 and IRE1. TRAF2 and TRAF5 therefore regulate diverse physiological roles, ranging from T and B cell signaling and inflammatory responses to organogenesis and cell survival. The major pathways mediated by TRAF2 and TRAF5 are the classical and alternative pathways of NF-κB activation, and MAPK and JNK activation. TRAF2 is heavily regulated by ubiquitin signals, and many of the signaling functions of TRAF2 are mediated through its RING domain and likely its own role as an E3 ubiquitin ligase.


Endoplasmic Reticulum Stress Herpes Virus Entry Mediator Hypohidrotic Ectodermal Dysplasia Tumor Necrosis Factor Signaling NFkappaB Activation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Landes Bioscience and Springer Science+Business Media 2007

Authors and Affiliations

  • Ping-Yee Billie Au
  • Wen-Chen Yeh
    • 1
  1. 1.Campbell Family for Breast Cancer Research, University Health Network and Department of Medical BiophysicsUniversity of TorontoToranto

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