TRAF1 and Its Biological Functions

  • Soo Young Lee
  • Yongwon Choi
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 597)


Tumor necrosis factor (TNF) receptor-associated factor (TRAF)1 was originally identified based on its ability to interact with the cytosolic domain of TNF receptor type 2 (TNFR2). TRAF1 is unique among TRAF proteins in that it lacks RING domain found in the N-terminal regions of other TRAFs. TRAF1 can associate with multiple TNFR family members and can also bind several protein kinases and adaptor proteins suggesting that this protein likely possesses multiple functions in cytokine signaling networks. Although our understanding of TRAF1 functions and the underlying mechanisms at molecular and cellular levels has been advanced in recent years, much still needs to be learned before we have a full grasp of TRAF1 biology.


Tumor Necrosis Factor Receptor Tumor Necrosis Factor Receptor Superfamily Tumor Necrosis Factor Signaling Tumor Necrosis Factor Ligand Tumor Necrosis Factor Receptor Type 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Landes Bioscience and Springer Science+Business Media 2007

Authors and Affiliations

  • Soo Young Lee
  • Yongwon Choi
    • 1
  1. 1.Department of Pathology and Laboratory Medicine, Abramson Family Cancer Research InstituteUniversity of Pennsylvania School of MedicinePhiladelphiaUSA

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