The LTβR Signaling Pathway

  • Paula S. Norris
  • Carl F. Ware
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 597)


The lymphotoxin-β receptor (LTβR, TNFRSF3) signaling pathway activates gene transcription programs and cell death important in immune development and host defense. The TNF receptor associated factors (TRAF)-2, 3 and 5 function as adaptors linking LTβR signaling targets. Interestingly, TRAF deficient mice do not phenocopy mice deficient in components of the LTβR pathway, presenting a conundrum. Here, an update of our understanding and models of the LTβR signaling pathway are reviewed, with a focus on this conundrum.


NFKB Activation Peripheral Lymphoid Organ Tumor Necrosis Factor Superfamily Tumor Necrosis Factor Receptor Associate Factor Herpes Virus Entry Mediator 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Landes Bioscience and Springer Science+Business Media 2007

Authors and Affiliations

  • Paula S. Norris
  • Carl F. Ware
    • 1
  1. 1.Division of Molecular ImmunologyLa Jolla Institute for Allergy and ImmunologySan DiegoUSA

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