TRAFs in RANK Signaling

  • Bryant G. Darnay
  • Arnaud Besse
  • Ann T. Poblenz
  • Betty Lamothe
  • Jürg J. Jacoby
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 597)


Members of the tumor necrosis factor (TNF) family govern many diverse physiological and cellular responses including cellular proliferation, differentiation, and apoptosis. Ligands of this family interact through a distinct set of specific receptors that lack enzymatic activity and therefore are dependent on the association of adaptor molecules. One receptor/ligand pair known as receptor activator of nuclear factor-kappa B (RANK) and RANK ligand (RANKL) regulates bone remodeling, mammary gland development, and lymph node organogenesis. RANK interacts with five members of the TNF receptor-associated factor (TRAF) family, of which TRAF6 is indispensable for its signaling capability. An accumulation of evidence from various research laboratories indicates TRAFs, but more importantly TRAF6, is the key to understanding how RANKL links cytoplasmic signaling to the nuclear transcriptional program.


Osteoclast Differentiation Osteoclast Formation Rank Signaling Tartrate Resistant Acid Phosphatase Ring Domain 


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Copyright information

© Landes Bioscience and Springer Science+Business Media 2007

Authors and Affiliations

  • Bryant G. Darnay
    • 1
  • Arnaud Besse
  • Ann T. Poblenz
  • Betty Lamothe
  • Jürg J. Jacoby
  1. 1.Department of Experimental TherapeuticsUniversity of Texas M.D. Anderson Cancer CenterHoustonUSA

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