Mitochondria pp 117-150 | Cite as

Regulation of Pyruvate and Amino Acid Metabolism

  • Thomas C. Vary
  • Wiley W. Souba
  • Christopher J. Lynch
Part of the Advances in Biochemistry in Health and Disease book series (ABHD, volume 2)


Amino acids serve multiple functions in body ranging from the basic building blocks of proteins to precursors for glucose and urea synthesis. The circulating amino acids are generally categorized with respect to either their function (gluconeogenic or ketogenic) or availability (essential or nonessential). The metabolism of amino acids is directly controlled through mitochondrial function. In addition, there is growing evidence that amino acids participate in processes that control cellular functions. Amino acids are not only utilized as metabolic substrates, increasingly it has become evident they also participate in the regulation of various cellular processes including protein synthesis, glycogen synthesis and autophagy. The regulatory processes affected by amino acids may involve mitochondria. This chapter will provide an overview of the current understanding of the role of the mitochondrial function in controlling amino acid metabolism.


Pyruvate Dehydrogenase Branch Chain Amino Acid Maple Syrup Urine Disease Pyruvate Dehydrogenase Complex Ethyl Pyruvate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  • Thomas C. Vary
  • Wiley W. Souba
  • Christopher J. Lynch

There are no affiliations available

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