Regulation of Mitochondrial Fuel Handling by the Peroxisome Proliferator-Activated Receptors

  • Mary C. Sugden
  • Mark J. Holness
Part of the Advances in Biochemistry in Health and Disease book series (ABHD, volume 2)


Within the body, lipids are essential for many aspects of cellular processes, and the PPARS are sensors of lipids that act to regulate gene expression. As lipid metabolism and glucose homeostasis are intrinsically related, these transcription factors exert a profound influence on the selection of metabolic fuels for ATP generation via mitochondrial oxidation. This chapter therefore focuses on the role of the PPARs as key coordinators of the selection of metabolic fuels used for mitochondrial ATP production.


Pyruvate Dehydrogenase Kinase PPAR Activation PPAR Ligand PPAR Null Mouse PPAR Target Gene 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  • Mary C. Sugden
  • Mark J. Holness

There are no affiliations available

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