Regulation of Fatty Acid Oxidation of the Heart

  • Clifford D. L. Folmes
  • Gary D. Lopaschuk
Part of the Advances in Biochemistry in Health and Disease book series (ABHD, volume 2)


The heart has very high energy demands and requires a large amount of ATP in order to maintain contraction and ionic homeostasis (Opie 1998). To meet this high demand, the heart acts as a metabolic omnivore, metabolizing a variety of carbon substrates, including carbohydrates (glucose, lactate, and pyruvate), fatty acids, and ketone bodies (Neely and Morgan 1974; King and Opie 1998; Stanley et al. 2005). Under normal aerobic conditions, the heart preferentially metabolizes fatty acids, which contribute between 60% and 80% of the required ATP (Lopaschuk et al. 1994a; Stanley and Chandler 2002), with carbohydrates contributing the residual 20% to 40%. While there are many similarities in fatty acid oxidation in various tissues, the regulation of fatty acid oxidation in the heart can differ dramatically from regulation in tissues like liver, skeletal muscle and kidney.


Fatty Acid Oxidation Fatty Acid Uptake Fatty Acid Utilization Fatty Acid Transport Protein Fatty Acid Oxidation Enzyme 
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© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  • Clifford D. L. Folmes
  • Gary D. Lopaschuk

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