Mitochondria pp 305-322 | Cite as

Mitochondria and Their Role in Ischemia/Reperfusion Injury

  • Sebastian Phillip
  • James M. Downey
  • Michael V. Cohen
Part of the Advances in Biochemistry in Health and Disease book series (ABHD, volume 2)


Acute coronary occlusion is the leading cause of morbidity and mortality in the western world and according to the World Health Organization will be the major cause of death in the world as a whole by the year 2020 (Murray and Lopez 1997). The major complication of the sudden occlusion of a coronary artery is the loss of contractile myocardium served by that artery. The contractile dysfunction resulting from infarction of the ventricle is essentially permanent as the lost heart muscle cannot regenerate. The size of the resultant infarct is the decisive determinant of the extent and severity of remodeling (Pfeffer et al. 1991) and of the prognosis of patients after myocardial infarction (St. John Sutton et al. 1997). Fast revascularization will result in less myocardial necrosis; nevertheless congestive heart failure secondary to myocardial infarction is still common.


Ischemic Precondition Mitochondrial Permeability Transition Pore mPTP Opening Isolate Rabbit Heart Index Ischemia 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  • Sebastian Phillip
  • James M. Downey
  • Michael V. Cohen

There are no affiliations available

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