Mitochondria pp 221-238 | Cite as

Mitochondrial Ion Channels

  • Brian O’Rourke
Part of the Advances in Biochemistry in Health and Disease book series (ABHD, volume 2)


The maintenance of a large electrochemical driving force for protons across the mitochondrial inner membrane is essential for the production of ATP through oxidative phosphorylation. At face value, the opening of energy dissipating ion channels in the mitochondria would be unfavorable for energy transduction, but a wealth of evidence now indicates that selective (and some non-selective) ion channels may become active under various physiological or pathophysiological conditions.


Mitochondrial Permeability Transition Pore Voltage Dependent Anion Channel Physiol Heart Circ Mitochondrial KATP Channel Membrane Anion Channel 


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  • Brian O’Rourke

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