Genomic DNA Copy Number Alterations in Mouse Cancer Models and Human Cancer



The development of solid tumors is associated with the acquisition of genetic and epigenetic alterations. Although these changes may be brought about at the genomic level in a variety of ways, genomic DNA copy number aberrations are particularly frequent in solid tumors and are expected to contribute to tumor evolution by copy number induced alterations in gene expression. Mouse cancer models recapitulate genomic alterations observed in human tumors to varying degrees. Comparison of aberrations in tumor genomes in mouse models and human cancer has facilitated the identification of oncogenes and tumor suppressors, as well as polymorphic variants contributing to individual cancer susceptibility.


Oral Squamous Cell Carcinoma Comparative Genomic Hybridization Genomic Alteration Copy Number Change Array Comparative Genomic Hybridization 


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Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  1. 1.Department of Laboratory Medicine and UCSF Helen Diller Family Comprehensive Cancer Center, Cancer Research InstituteUniversity of California San FranciscoSan FranciscoUSA

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