The Development and Use of Genetically Tractable Preclinical Mouse Models
Mouse models have made fundamental contributions to our understanding of tumor progression and the basic molecular genetics of cancer. However, these models have only recently been adapted to effectively study the biology of therapeutic response. The emerging use of preclinical mouse models to study cancer therapy has required the development of tractable genetic systems to rapidly generate tumors bearing complex genetic lesions, as well as an improved understanding of how to most appropriately model human cancer treatment in the mouse. In this chapter, I discuss recent approaches to developing preclinical systems that can be used to effectively model human cancer therapy. A particular focus of this discussion is the emerging set of genetic tools that can be used to accurately recapitulate relevant therapeutic settings. Many of these tools have only been developed in the past several years and speak to the enormous potential of mouse models to fundamentally improve current drug development platforms and inform the further development of personalized cancer therapy.