Src Family Tyrosine Kinases: Implications for Mammary Tumor Progression
This chapter reviews the role of c-Src tyrosine kinase in mammary tumor progression. In addition to highlighting the molecular mechanism by which c-Src is activated, we explore the evidence of supporting a role for c-Src in both murine and human breast cancers. In particular, this review highlights the use of mouse models to resect the role of c-Src in mammary tumor progression. These genetic analyses provide important insight into the role of c-Src signaling pathway in oncogene-induced mammary tumor progression.