Src Family Tyrosine Kinases: Implications for Mammary Tumor Progression

  • Richard Marcotte
  • William J. Muller


This chapter reviews the role of c-Src tyrosine kinase in mammary tumor progression. In addition to highlighting the molecular mechanism by which c-Src is activated, we explore the evidence of supporting a role for c-Src in both murine and human breast cancers. In particular, this review highlights the use of mouse models to resect the role of c-Src in mammary tumor progression. These genetic analyses provide important insight into the role of c-Src signaling pathway in oncogene-induced mammary tumor progression.


Vascular Endothelial Growth Factor Focal Adhesion Kinase Focal Adhesion Mammary Gland Tumor Integrin Engagement 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  1. 1.Ontario Cancer InstituteUniversity of TorontoTorontoCanada
  2. 2.Goodman Cancer CenterMontrealCanada

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