Abstract
This chapter reviews the role of c-Src tyrosine kinase in mammary tumor progression. In addition to highlighting the molecular mechanism by which c-Src is activated, we explore the evidence of supporting a role for c-Src in both murine and human breast cancers. In particular, this review highlights the use of mouse models to resect the role of c-Src in mammary tumor progression. These genetic analyses provide important insight into the role of c-Src signaling pathway in oncogene-induced mammary tumor progression.
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Marcotte, R., Muller, W.J. (2012). Src Family Tyrosine Kinases: Implications for Mammary Tumor Progression. In: Green, J., Ried, T. (eds) Genetically Engineered Mice for Cancer Research. Springer, New York, NY. https://doi.org/10.1007/978-0-387-69805-2_16
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