Roles of p53 and pRB Tumor Suppressor Networks in Human Cancer: Insight from Studies in the Engineered Mouse
The retinoblastoma (RB) and p53 tumor suppressor genes were identified more than 20 years ago and have since been implicated in multiple cellular processes, including the control of cell cycle progression, cell death, and cellular differentiation. A number of recent reviews explain in detail how RB and p53 normally prevent the development of cancer (Burkhart and Sage 2008; van den Heuvel and Dyson 2008; Sherr 2004; Vousden and Lu 2002; Levine et al. 2006). Our goal here is not to provide an exhaustive description of how these two factors function in mammalian cells, but rather to summarize some key aspects of their biology and to discuss areas in the field that are thought-provoking. In particular, we focus on how mouse models associated with perturbed of RB and p53 function have influenced our vision of the mechanisms of tumorigenesis.
KeywordsHuman Retinoblastoma Genetically Engineer Mouse Familial Retinoblastoma Pituitary Cancer Retinoblastoma Development
Genetically engineered mice
Mouse embryo fibroblasts
Small cell lung carcinoma