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Insulin and New Insulin Analogues with Focus on Type 2 Diabetes

  • Sten Madsbad

The underlying insulin resistance and impaired insulin secretion in patients with type 2 diabetes worsen over time, necessitating the use of antidiabetic drugs, often in combination, to control glycaemic levels [1]. From the UKPD study the main explanation for the progressive history of type 2 diabetes seems to be a failure of beta-cell function over time [2], while insulin resistance may be more constant from diagnosis [2]. Therefore, it is not surprising that insulin treatment is necessary in most patients 10–15 years after diagnosis to maintain of HbA1c level as close to normal as is safely possible [2]. A consensus recommendation for the treatment of type 2 diabetes has recently been published [1].

Keywords

Human Insulin Insulin Glargine Basal Insulin Insulin Analogue Insulin Aspart 
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Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  • Sten Madsbad
    • 1
  1. 1.Department of Endocrinology, Hvidovre HospitalUniversity of CopenhagenDenmark

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