Pharmacotherapy of Diabetes
Editorials in major journals may provide an important review of opinion regarding diabetes and pharmacotherapy of diabetes as well as the nature of treatment. Many years ago Siperstein argued against support of rigid glycemic control. According to Siperstein [1, 2] most studies on better glycemic control were inconclusive. This left the clinicians with the impression that complications were related to genetic patterns and not to the phenotypic risk factors occurring with diabetes. Later he argued that the muscle capillary basement membrane could be influenced by the level of blood glucose, but whether this was related also to other organs such as the kidney and the retina was in doubt, thus arguing against results in the important work of Østerby. I believe that this really influenced the clinical practice in the USA for many years.
KeywordsGlycemic Control Diabetic Nephropathy Islet Transplantation Pancreas Transplantation United Kingdom Prospective Diabetes Study
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- 8.Mogensen CE. Combined high blood pressure and glucose in type 2 diabetes: double jeopardy. British trials show clear effects of treatment, especially blood pressure reduction. Br Med J; 1998; 317:693–694.Google Scholar
- 17.Ingelfinger JR, Solomon CG. Angiotensin-converting-enzyme inhibitors for impaired glucose tolerance – is there still hope? N Engl J Med 355:1608–1610.Google Scholar
- 25.Nathan DM. Finding new treatments for diabetes – how many, how fast… how good? N Engl J Med 356:437–440.Google Scholar
- 29.Nissen SE, Wolski K. Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes. N Engl J Med 2007;356:xx–xx.Google Scholar
- 30.Singh S, Loke YK, Furberg CD. Thiazolidinediones and Heart Failure: A Teleo-Analysis. Diabetes Care 2007; DOI:10.2337/dc07–0141.Google Scholar
- 31.Home PD, Pocock SJ, Beck-Nielsen H, et al. Rosiglitazone evaluated for cardiovascular outcomes – an interim analysis. N Engl J Med 2007;DOI:0.1056/NEJMoa073394.Google Scholar