Pharmacotherapy of Diabetes

  • Carl Erik Mogensen

Editorials in major journals may provide an important review of opinion regarding diabetes and pharmacotherapy of diabetes as well as the nature of treatment. Many years ago Siperstein argued against support of rigid glycemic control. According to Siperstein [1, 2] most studies on better glycemic control were inconclusive. This left the clinicians with the impression that complications were related to genetic patterns and not to the phenotypic risk factors occurring with diabetes. Later he argued that the muscle capillary basement membrane could be influenced by the level of blood glucose, but whether this was related also to other organs such as the kidney and the retina was in doubt, thus arguing against results in the important work of Østerby. I believe that this really influenced the clinical practice in the USA for many years.


Glycemic Control Diabetic Nephropathy Islet Transplantation Pancreas Transplantation United Kingdom Prospective Diabetes Study 
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Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  • Carl Erik Mogensen
    • 1
  1. 1.Medical DepartmentAarhus University HospitalDenmark

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