Glitazones improve insulin sensitivity through the activation of the nuclear receptor, peroxisome proliferator- activated receptor-γ (PPAR-γ). In addition to sensitizing cells to insulin, the PPAR-γ may affect bone. Thus, an increasing body of evidence suggests that genetic mutations in the PPAR-γ as well as treatment with glitazones affect skeletal tissue.


Bone Mineral Density Polycystic Ovary Syndrome Marrow Adipocyte Bone Marrow Adipocyte Breast Adipose Tissue 


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© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  • Lars Rejnmark
    • 1
  1. 1.Medical DepartmentAarhus University HospitalDenmark

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