Lineage-Specific Transcription Factor Aberrations in AML

  • Beatrice U. Mueller
  • Thomas Pabst
Part of the Cancer Treatment and Research book series (CTAR, volume 145)


Transcription factors play a key role in the commitment of hematopoietic stem cells to differentiate into specific lineages [78]. This is particularly important in that a block in terminal differentiation is the key contributing factor in acute leukemias. This general theme of the role of transcription factors in differentiation may also extend to other tissues, both in terms of normal development and cancer. Consistent with the role of transcription factors in hematopoietic lineage commitment is the frequent finding of aberrations in transcription factors in AML patients. Here, we intend to review recent findings on aberrations in lineage-restricted transcription factors as observed in patients with acute myeloid leukemia (AML).


Acute Myeloid Leukemia Acute Promyelocytic Leukemia Acute Myeloid Leukemia Patient RUNX1 Gene Runt Domain 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



Research grants: This work was supported by grants from the Swiss National Science Foundation SF 3100A0-100445 to B.U.M. and SF 310000-109388 to TP.We apologize to all authors whose contribution to the field could not be cited due to limitations in space.


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© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  1. 1.Department of Internal MedicineUniversity HospitalBernSwitzerland
  2. 2.Department of OncologyUniversity HospitalBernSwitzerland

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