Chromosomal Translocations in AML: Detection and Prognostic Significance

  • Nallasivam Palanisamy
Part of the Cancer Treatment and Research book series (CTAR, volume 145)


Clonal chromosome abnormalities are hallmarks of various cancer types. Non-random chromosome translocations have been identified in hematological malignancies over five decades due to their ability to yield informative metaphases. Among the various chromosome aberrations commonly found in different cancer types including deletions, duplications, and aneuploidy, balanced reciprocal translocations have been identified with remarkable specificity in hematological malignancies and soft tissue sarcomas. Recurrent chromosome aberrations are used as markers for diagnosis, prognosis, and treatment follow-up. The fusion and deregulated genes cloned from the site of translocation breakpoints are implicated in tumorigenesis. It has been well established that common molecular consequences of non-random reciprocal translocations result in the formation of a fusion gene from the breakpoints in the introns of two different genes on the same or different chromosome. Most of the fusion genes described in hematological malignancies are transcription factor genes and tyrosine kinases, conferring proliferative advantage to the leukemic clone.


Acute Myeloid Leukemia Chronic Myeloid Leukemia Acute Myeloid Leukemia Patient Translocation Breakpoint Promyelocytic Leukemia Zinc Finger 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



I thank Cancer Genetics Inc, New Jersey, USA for the inv (16) probe FISH images. This work was supported by grants from National Institutes of Health, NIH SBIR phase I grant 1R43CA091532-01 and Agency for Science Technology and Research (A-STAR) Singapore. Wilson GOH Wen Bin, for his assistance in the preparation of this article


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© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  1. 1.Department of Pathology, Michigan Center for Translational PathologyUniversity of MichiganAnn ArborUSA

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