Immunotherapy of AML

  • Gheath Alatrash
  • Jeffrey J. Molldrem
Part of the Cancer Treatment and Research book series (CTAR, volume 145)


The applications of chemotherapy for the treatment of AML have been unchanged over the past three decades, with only 30% of patients demonstrating disease-free survival (DFS) [118]. Despite achieving CR following induction chemotherapy, the majority of patients relapse and succumb to their disease [6]. In view of the limitations encountered by cytarabine/anthracycline based regimes, attention has shifted to immunotherapy as a means to treat AML and provide significant long-term DFS. This chapter will discuss the role of the immune system and recent advances in immunotherapy for the treatment of AML, focusing on cellular and non-cellular approaches.


Natural Killer Cell Chronic Myeloid Leukemia Hematopoietic Stem Cell Transplant Allogeneic Hematopoietic Stem Cell Transplant Donor Lymphocyte Infusion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Gheath Alatrash
    • 1
  • Jeffrey J. Molldrem
    • 2
  1. 1.Division of Cancer MedicineUniversity of Texas MD, Anderson Cancer CenterHoustonUSA
  2. 2.Division of Cancer MedicineUniversity of Texas MD Anderson Cancer CenterHoustonUSA

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