Apoptosis in Leukemias: Regulation and Therapeutic Targeting

  • Ismael Samudio
  • Marina Konopleva
  • Bing Carter
  • Michael Andreeff
Part of the Cancer Treatment and Research book series (CTAR, volume 145)


Nearly 25 years after the seminal publication of John Foxton Kerr that first described apoptosis, the process of regulated cell death, our understanding of this basic physiological phenomenon is far from complete [39]. From cardiovascular disease to cancer, apoptosis has assumed a central role with broad ranging therapeutic implications that depend on a complete understanding of the molecular events involved in orchestrating cellular demise. More than 145,301 (as of April 2008) published works on this subject have increased our understanding of this process, yet have also identified an incredibly complex regulatory system that is critical for development and is at the core of many diseases, challenging scientists and clinicians to step into its molecular realm and modulate its circuitry for therapeutic purposes. This chapter will review our understanding of the molecular circuitry that controls apoptosis in leukemia and the pharmacological manipulations of this pathway that may yield therapeutic benefit.


Death Induce Signaling Complex Require Caspase Activation Death Induce Signaling Complex Formation Sensitize Leukemia Cell Primary Leukemia Sample 


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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Ismael Samudio
    • 1
  • Marina Konopleva
    • 2
  • Bing Carter
    • 1
  • Michael Andreeff
    • 3
  1. 1.Section of Molecular Hematology and Therapy, Department of Stem Cell Transplantation and Cellular TherapyThe University of Texas MD Anderson Cancer CenterHoustonUSA
  2. 2.Section of Molecular Hematology and Therapy, Department of LeukemiaThe University of Texas MD Anderson Cancer CenterHoustonUSA
  3. 3.Department of Blood and Marrow TransplantationUniversity of Texas MD Anderson Cancer CenterHoustonUSA

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