MicroRNAs: New Players in AML Pathogenesis
MicroRNAs (miRNAs) constitute a class of regulatory non-coding RNAs involved in gene silencing pathways. They are single-stranded RNA molecules ranging from 19 to 25 nucleotides and may be considered the natural counterparts of small interfering RNAs (siRNAs). Because of their fine regulation of gene expression at the post-transcriptional level, miRNAs are crucial players in several regulatory pathways, including developmental timing, organogenesis, differentiation, hematopoiesis, apoptosis, cell proliferation, and tumorigenesis . The regulatory network of miRNA and messenger RNA (mRNA) is combinatorial and unique to each cell type; in fact, a single miRNA molecule can bind and repress several different mRNAs and multiple miRNAs cooperate to control a single mRNA target, in a cell-customized manner . Because of their pleiotropic gene expression regulation potential, miRNAs are also considered cellular micromanagers [2, 33]
KeywordsChronic Lymphocytic Leukemia miRNA Expression Acute Myelogenous Leukemia miRNA Expression Profile miRNA Expression Pattern
Dr. Calin is supported by the CLL Global Research Foundation, and in part as a University of Texas System Regents Research Scholar and a Fellow of The University of Texas MD Anderson Research Trust. Dr. Jasra participated in the preparation of this chapter during her observership in Dr. Calin’s laboratory.
- 31.Lagos-Quintana M, Rauhut R, Lendeckel W, Tuschl T. Identification of novel genes coding for small expressed RNAs. Science (New York, NY). 2001;294:853–858.Google Scholar
- 32.Lau NC, Lim LP, Weinstein EG, Bartel DP. An abundant class of tiny RNAs with probable regulatory roles in Caenorhabditis elegans. Science (New York, NY). 2001;294:858–862.Google Scholar
- 34.Lee Y, Jeon K, Lee JT, Kim S, Kim VN. MicroRNA maturation: stepwise processing and subcellular localization. EMBO J. 2002;21:4663–4670.Google Scholar
- 40.Nakao M, Horiike S, Fukushima-Nakase Y, et al. Novel loss-of-function mutations of the haematopoiesis-related transcription factor, acute myeloid leukaemia 1/runt-related transcription factor 1, detected in acute myeloblastic leukaemia and myelodysplastic syndrome. Br J Haematol. 2004;125:709–719.PubMedCrossRefGoogle Scholar