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MicroRNAs: New Players in AML Pathogenesis

  • Milena S. Nicoloso
  • Bharti Jasra
  • George A. Calin
Chapter
Part of the Cancer Treatment and Research book series (CTAR, volume 145)

Abstract

MicroRNAs (miRNAs) constitute a class of regulatory non-coding RNAs involved in gene silencing pathways. They are single-stranded RNA molecules ranging from 19 to 25 nucleotides and may be considered the natural counterparts of small interfering RNAs (siRNAs). Because of their fine regulation of gene expression at the post-transcriptional level, miRNAs are crucial players in several regulatory pathways, including developmental timing, organogenesis, differentiation, hematopoiesis, apoptosis, cell proliferation, and tumorigenesis [2]. The regulatory network of miRNA and messenger RNA (mRNA) is combinatorial and unique to each cell type; in fact, a single miRNA molecule can bind and repress several different mRNAs and multiple miRNAs cooperate to control a single mRNA target, in a cell-customized manner [33]. Because of their pleiotropic gene expression regulation potential, miRNAs are also considered cellular micromanagers [2, 33]

Keywords

Chronic Lymphocytic Leukemia miRNA Expression Acute Myelogenous Leukemia miRNA Expression Profile miRNA Expression Pattern 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgments

Dr. Calin is supported by the CLL Global Research Foundation, and in part as a University of Texas System Regents Research Scholar and a Fellow of The University of Texas MD Anderson Research Trust. Dr. Jasra participated in the preparation of this chapter during her observership in Dr. Calin’s laboratory.

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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Milena S. Nicoloso
    • 1
  • Bharti Jasra
    • 1
  • George A. Calin
    • 2
  1. 1.Department of Experimental Therapeutics and Department of Cancer GeneticsThe University of Texas MD Anderson Cancer CenterHoustonUSA
  2. 2.Department of Experimental Therapeutics and Department of Cancer GeneticsThe University of Texas MD Anderson Cancer CenterHoustonUSA

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